Annie Joseph Kruger, MD,PhD
Provider is directly employed by MedStar Health

4.7 out of 5 (61 reviews)

Specialities: Hepatology, Gastroenterology

Languages: English


About me

Board-certified in gastroenterology and internal medicine, Annie J. Kruger, MD, PhD, is a gastroenterologist specializing in a range of metabolic, infectious, and autoimmune liver diseases. In both her clinical and research work, she has a particular interest in understanding, managing, and developing new therapeutics for nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH) and resulting conditions.

Dr. Kruger received her combined MD/PhD from the University of Massachusetts School of Medicine, following which she completed her Internal Medicine residency, Gastroenterology fellowship, and research post-doctoral fellowship at the Massachusetts General Hospital. Prior to medical school, she had received an MSPH in Immunology and Infectious Disease from Harvard University and worked as a consultant for the pharmaceutical and managed care industries for several years.
A committed researcher and the recipient of several foundation and NIH grants to date, Dr. Kruger’s work has appeared in GastroenterologyHepatology, Journal of Hepatology, Hepatology Communications and the Journal of Infectious Diseases, among other peer-reviewed publications. She is a member of the American Association for the Study of Liver Diseases and the American Gastroenterological Association.  

In her practice, Dr. Kruger believes in providing personalized care for each patient with a comprehensive approach to improving their health. Her approach involves effectively utilizing diagnostic tests to arrive at an accurate diagnosis, prescribing optimal medical treatments for each unique GI disease, and addressing patients' nutritional and psychosocial needs to arrive at the best clinical outcome for her patients. In addition to English, Dr. Kruger speaks conversational Spanish and Portuguese.

Clinical areas of focus

  • Abdominal Bloating
  • Abdominal Distention
  • Abdominal Pain
  • Abnormal Bowel Movement
  • Abnormal Stool
  • Altered Bowel Habits
  • Anal Fissure
  • Bleeding Hemorrhoids
  • Blood In Stool
  • Chronic Diarrhea
  • Colonoscopy
  • Constipation
  • Diarrhea
  • Dysphagia
  • Epigastric Pain
  • Gastroesophageal Reflux Disease
  • Gastrointestinal Bleeding
  • Helicobacter Pylori
  • Hemorrhoids
  • Melena
  • Nausea
  • Postprandial Diarrhea
  • Rectal Bleeding
  • Rectal Pain
  • Stomach Cramps
  • Stomach Pain
  • Swallowing Problem
  • Vomiting
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Conditions and procedures

Conditions I treat

  • Abdominal Bloating
  • Abdominal Distention
  • Abdominal Pain
  • Abnormal Amylase Blood Test
  • Abnormal Bowel Movement
  • Abnormal Liver Function Blood Test
  • Abnormal Stool
  • Achalasia
  • Acute Pancreatitis
  • Alcoholic Liver Disease
  • Allergic Esophagitis
  • Altered Bowel Habits
  • Anal Fissure
  • Anal Fistula
  • Anal Itching
  • Anal Pain
  • Anal Spasm
  • Annular Pancreas
  • Anorexia
  • Autoimmune Enteropathy
  • Autoimmune Hepatitis
  • Barretts Esophagus
  • Benign Neoplasm Of Colon
  • Biliary Tract Disease
  • Bleeding Hemorrhoids
  • Blood In Stool
  • Bowel Dysmotility
  • Bright Red Blood Per Rectum
  • Celiac Disease
  • Choking Sensation
  • Cholangitis
  • Cholecystitis
  • Cholelithiasis
  • Cholestasis
  • Chronic Abdominal Pain
  • Chronic Diarrhea
  • Chronic Pancreatitis
  • Cirrhosis
  • Clostridium Difficile
  • Colitis
  • Collagenous Colitis
  • Colonic Inertia
  • Colonic Polyps
  • Constipation
  • Crohns Disease
  • Cyclic Vomiting Syndrome
  • Diarrhea
  • Digestive Disorders
  • Diverticular Disease
  • Diverticulitis
  • Drug Induced Liver Injury
  • Duodenal Ulcer
  • Duodenitis
  • Dyspepsia
  • Dysphagia
  • Early Satiety
  • Elevated Alkaline Phosphatase Level
  • Elevated Lipase
  • Eosinophilic Colitis
  • Eosinophilic Enteritis
  • Eosinophilic Esophagitis
  • Eosinophilic Gastritis
  • Epigastric Pain
  • Eructation
  • Esophageal Cancer
  • Esophageal Disease
  • Esophageal Diverticulum
  • Esophageal Mass
  • Esophageal Motility Disorders
  • Esophageal Spasm
  • Esophageal Stricture
  • Esophageal Thickening
  • Esophageal Ulcer
  • Esophageal Varices
  • Esophagitis
  • Family History Of Colon Cancer
  • Family History Of Colon Polyps
  • Fatty Liver
  • Fecal Impaction
  • Fecal Incontinence
  • Flatulence
  • Focal Nodular Hyperplasia
  • Gallbladder Disease
  • Gallbladder Polyp
  • Gastric Ulcer
  • Gastritis
  • Gastroenteritis
  • Gastroesophageal Reflux Disease
  • Gastrointestinal Amyloid
  • Gastrointestinal Bleeding
  • Gastrojejunal Ulcer
  • Gastroparesis
  • Giardiasis
  • Gluten Sensitivity
  • Helicobacter Pylori
  • Hematemesis
  • Hemochromatosis
  • Hemorrhoids
  • Hepatitis
  • Hepatitis B
  • Hepatitis C
  • Hepatomegaly
  • Hiatal Hernia
  • Ileitis
  • Inflammatory Bowel Disease
  • Intestinal Obstruction
  • Intractable Vomiting
  • Iron Deficiency Anemia
  • Irritable Bowel Syndrome
  • Ischemic Bowel
  • Ischemic Colitis
  • Jaundice
  • Lactose Intolerance
  • Left Upper Quadrant Pain
  • Liver Disease
  • Liver Mass
  • Lymphocytic Colitis
  • Lynch Syndrome
  • Malabsorption
  • Malignant Neoplasm Of Stomach
  • Melena
  • Microscopic Colitis
  • Motility Disorders
  • Nausea
  • Non Alcoholic Fatty Liver Disease
  • Non Alcoholic Steatohepatitis
  • Obstipation
  • Obstructive Jaundice
  • Odynophagia
  • Ogilvie Syndrome
  • Pancreas Divisum
  • Pancreatic Cyst
  • Pancreatic Insufficiency
  • Pancreatic Pseudocyst
  • Pancreaticobiliary Disease
  • Pancreatitis
  • Peptic Ulcer
  • Peritonitis
  • Pernicious Anemia
  • Personal History Of Colonic Polyps
  • Peutz Jeghers Syndrome
  • Polyposis Syndrome
  • Portal Hypertension
  • Portal Hypertensive Gastropathy
  • Positive Hemoccult Fecal Occult Blood Test
  • Postprandial Diarrhea
  • Primary Biliary Cirrhosis
  • Proctitis
  • Rectal Bleeding
  • Rectal Pain
  • Right Lower Quadrant Pain
  • Right Upper Quadrant Pain
  • Short Bowel Syndrome
  • Small Bowel Disease
  • Steatorrhea
  • Stomach Cramps
  • Stomach Disorders
  • Stomach Pain
  • Swallowing Problem
  • Toxic Liver Injury
  • Ulcerative Colitis
  • Ulcerative Proctitis
  • Vomiting
  • Whipples Disease
  • Wilsons Disease
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Procedures I perform

  • Bravo Ph Test
  • Colon Polypectomy
  • Colonoscopy
  • Esophageal Variceal Band Ligation
  • Esophagogastroduodenoscopy Egd
  • Feeding Tube Management
  • Gastrointestinal Gi Cancer Screening
  • Gastroscopy
  • Peg Percutaneous Endoscopic Gastrostomy
  • Proctosigmoidoscopy
  • Sigmoidoscopy
  • Single Balloon Enteroscopy
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Practice locations

Distance from Change LocationEnter your Location

3800 Reservoir Road Northwest
Washington, DC, 20007


Fax 877-303-1462

Get Directions

miles away

Fax 877-303-1462


Board Certification: American Board of Internal Medicine, Gastroenterology

Board Certification: American Board of Internal Medicine, Internal Medicine

Fellowship Program: Massachusetts General Hospital (2018)

Residency Program: Massachusetts General Hospital (2013)

Medical School: University of Massachusetts (2011)

Graduate Education: University of Massachusetts (2011)


  • GHUCCTS KL2 Scholar (2019 - 2022) MGUH Department of Medicine Pilot Grant Recipient (2020) NIH NIDDK F32 Grant Recipient (2016-2018)

News and publications

Kruger AJ. Can Macrophages in Cirrhotic Ascites Fluid Predict Clinical Outcome in Spontaneous Bacterial Peritonitis?. Gastroenterology. 2020 May;158(6):1540-1543. doi: 10.1053/j.gastro.2020.02.040. Epub 2020 Mar 2. PubMed PMID: 32135164; PubMed Central PMCID: PMC7292615.


Tucker RD, Ciofoaia V, Nadella S, Gay MD, Cao H, Huber M, Safronenka A, Shivapurkar N, Kallakury B, Kruger AJ, Kroemer AHK, Smith JP. A Cholecystokinin Receptor Antagonist Halts Nonalcoholic Steatohepatitis and Prevents Hepatocellular Carcinoma. Dig Dis Sci. 2020 Jan;65(1):189-203. doi: 10.1007/s10620-019-05722-3. Epub 2019 Jul 11. PubMed PMID: 31297627; PubMed Central PMCID: PMC6946881.


Kim MY, Kruger AJ, Jeong JY, Kim J, Shin PK, Kim SY, Cho JY, Hahm KB, Hong SP. Combination Therapy with a PI3K/mTOR Dual Inhibitor and Chloroquine Enhances Synergistic Apoptotic Cell Death in Epstein-Barr Virus-Infected Gastric Cancer Cells. Mol Cells. 2019 Jun 30;42(6):448-459. doi: 10.14348/molcells.2019.2395. PubMed PMID: 31085812; PubMed Central PMCID: PMC6602147.


Duan X, Liu X, Li W, Holmes JA, Kruger AJ, Yang C, Li Y, Xu M, Ye H, Li S, Liao X, Sheng Q, Chen D, Shao T, Cheng Z, Kaj B, Schaefer EA, Li S, Chen L, Lin W, Chung RT. Microrna-130a Downregulates HCV Replication through an atg5-Dependent Autophagy Pathway. Cells. 2019 Apr 10;8(4). doi: 10.3390/cells8040338. PubMed PMID: 30974864; PubMed Central PMCID: PMC6523735.


Lidofsky A, Holmes JA, Feeney ER, Kruger AJ, Salloum S, Zheng H, Seguin IS, Altinbas A, Masia R, Corey KE, Gustafson JL, Schaefer EA, Hunt PW, Deeks S, Somsouk M, Chew KW, Chung RT, Alatrakchi N. Macrophage Activation Marker Soluble CD163 Is a Dynamic Marker of Liver Fibrogenesis in Human Immunodeficiency Virus/Hepatitis C Virus Coinfection. J Infect Dis. 2018 Sep 22;218(9):1394-1403. doi: 10.1093/infdis/jiy331. PubMed PMID: 29868909; PubMed Central PMCID: PMC6151081.


Kruger AJ, Fuchs BC, Masia R, Holmes JA, Salloum S, Sojoodi M, Ferreira DS, Rutledge SM, Caravan P, Alatrakchi N, Vig P, Lefebvre E, Chung RT. Prolonged cenicriviroc therapy reduces hepatic fibrosis despite steatohepatitis in a diet-induced mouse model of nonalcoholic steatohepatitis. Hepatol Commun. 2018 May;2(5):529-545. doi: 10.1002/hep4.1160. eCollection 2018 May. PubMed PMID: 29761169; PubMed Central PMCID: PMC5944590.


Salloum S, Holmes JA, Jindal R, Bale SS, Brisac C, Alatrakchi N, Lidofsky A, Kruger AJ, Fusco DN, Luther J, Schaefer EA, Lin W, Yarmush ML, Chung RT. Exposure to human immunodeficiency virus/hepatitis C virus in hepatic and stellate cell lines reveals cooperative profibrotic transcriptional activation between viruses and cell types. Hepatology. 2016 Dec;64(6):1951-1968. doi: 10.1002/hep.28766. Epub 2016 Oct 5. PubMed PMID: 27531241; PubMed Central PMCID: PMC5116014.


Brisac C, Salloum S, Yang V, Schaefer EA, Holmes JA, Chevaliez S, Hong J, Carlton-Smith C, Alatrakchi N, Kruger A, Lin W, Chung RT. IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-κB pathway. J Hepatol. 2016 Nov;65(5):972-979. doi: 10.1016/j.jhep.2016.06.028. Epub 2016 Jul 9. PubMed PMID: 27401546; PubMed Central PMCID: PMC5656012.


Mueller JL, Feeney ER, Zheng H, Misdraji J, Kruger AJ, Alatrakchi N, King LY, Gelrud L, Corey KE, Chung RT. Circulating Soluble CD163 is Associated with Steatohepatitis and Advanced Fibrosis in Nonalcoholic Fatty Liver Disease. Clin Transl Gastroenterol. 2015 Oct 8;6:e114. doi: 10.1038/ctg.2015.36. PubMed PMID: 26448455; PubMed Central PMCID: PMC4816035.


Kochupurakkal NM, Kruger AJ, Tripathi S, Zhu B, Adams LT, Rainbow DB, Rossini A, Greiner DL, Sayegh MH, Wicker LS, Guleria I. Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes. PLoS One. 2014;9(2):e89561. doi: 10.1371/journal.pone.0089561. eCollection 2014. PubMed PMID: 24586872; PubMed Central PMCID: PMC3938467.


Kruger AJ, Yang C, Lipson KL, Pino SC, Leif JH, Hogan CM, Whalen BJ, Guberski DL, Lee Y, Unger RH, Greiner DL, Rossini AA, Bortell R. Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats. Autoimmunity. 2011 Mar;44(2):137-48. doi: 10.3109/08916934.2010.482116. Epub 2010 Aug 9. PubMed PMID: 20695765; PubMed Central PMCID: PMC4172446.


Kruger AJ, Yang C, Tam SW, Hinerfeld D, Evans JE, Green KM, Leszyk J, Yang K, Guberski DL, Mordes JP, Greiner DL, Rossini AA, Bortell R. Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats. Exp Biol Med (Maywood). 2010 Nov;235(11):1328-37. doi: 10.1258/ebm.2010.010150. PubMed PMID: 20975081; PubMed Central PMCID: PMC4172443.


Pino SC, Kruger AJ, Bortell R. The role of innate immune pathways in type 1 diabetes pathogenesis. Curr Opin Endocrinol Diabetes Obes. 2010 Apr;17(2):126-30. doi: 10.1097/MED.0b013e3283372819. Review. PubMed PMID: 20125005; PubMed Central PMCID: PMC2905794.


Miller DM, Thornley TB, Pearson T, Kruger AJ, Yamazaki M, Shultz LD, Welsh RM, Brehm MA, Rossini AA, Greiner DL. TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade. J Immunol. 2009 May 1;182(9):5547-59. doi: 10.4049/jimmunol.0802077. PubMed PMID: 19380803; PubMed Central PMCID: PMC2721273.

Ratings and reviews

  • Provider explained things understandably

  • Provider listened carefully

  • Provider gave easy to understand instructions

  • Provider knew medical history

  • Provider showed respect

  • Provider spent enough time with patient

  • Aug 16, 2021

    I liked her a lot.

  • Jul 26, 2021

    Dr. Kruger explained everything to me using layman terms and very, very through in her explanations.

  • Jun 21, 2021

    Dr. Annie Kruger is an outstanding doctor. I was very impressed with her knowledge, her "bedside manner" and the time she gave me!