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Pre-Clinical Research Laboratory

MedStar Health Research Institute (MHRI) is committed to the advancement of healthcare through biomedical research, with the acknowledgement that advances in scientific knowledge not only come from clinical research, but from basic science and preclinical studies as well. Our two pre-clinical laboratories, one in Baltimore and one in DC, serve the research, testing and teaching programs that allow MedStar Health to move from bench to bedside to the greater community.

Current topics of interest for our researchers include

  • Pathophysiology of atherosclerosis and ischemia
  • Treatment and prevention of coronary heart disease (especially restenosis)
  • Mechanisms and pathophysiology of burn injury
  • Mechanisms and means for accelerating wound healing
  • Systems biology approaches for furthering understanding of the effects of stress on physical and mental health, including physiologic stressors and social defeat models.

Facilities

Our facilities can accommodate applications of cellular and molecular biology, bacteriology, histology, and pre-clinical evaluation techniques and methodologies. The core facility in Washington, DC, also provides resources for

  • Identifying genetic and molecular mechanisms of disease
  • Conducting preclinical feasibility and safety testing
  • Conducting preclinical trials testing therapeutic interventions
  • Providing data for regulatory approvals.

Capabilities

In accordance with U.S. Food and Drug Administration (FDA) regulations, the Research Institute has implemented a quality-control system that complies with Good Laboratory Practices (GLPs, 21 CFR Part 58). Our laboratory staff uses the GLP regulations as a guide to ensure that the data captured are of the highest quality and integrity. MHRI's commitment to providing an FDA-compliant environment is evidenced by our system reliability, documentation and standard operating procedures.

The laboratories also support non-GLP studies.

Certifications and Regulatory Oversight

  • United States Department of Agriculture
  • Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) accreditation.

IACUC

The Research Institute's IACUC operates under the guidelines of the AAALAC. Find out more here.

Contact

For more information on beginning your preclinical/basic science research, email [email protected].

Contact Information

Contact us to obtain more information about our research programs.

Search Principal Investigators

If you would like to learn more about MedStar's researchers and scientists, please visit our Principal Investigator search portal.