Mark Smith

mark smithMark Smith, MD, FACEP, is Chief Innovation Officer and Director of the MedStar Institute for Innovation (MI2), the innovation arm of MedStar Health. In this role, Dr. Smith leads a system-wide initiative to foster and catalyze innovation across the MedStar system. In addition, He serves as the Chairman of MedStar Emergency Physicians and is Professor and Chairman of Emergency Medicine at the Georgetown University School of Medicine.

Prior to his appointment as Director of MI2, Dr. Smith served as Chairman of Emergency Medicine at Washington Hospital Center for 14 years. Prior to that, he was Chairman and Professor of Emergency Medicine at the George Washington University Medical Center and Director of its Ronald Reagan Institute of Emergency Medicine.

Dr. Smith received his Bachelor of Arts in mathematics, philosophy and psychology with highest honors from Swarthmore College and a master's degree in computer science from Stanford University. His medical degree is from Yale University School of Medicine. He completed an internship in medicine at George Washington University Medical Center and a residency in emergency medicine at Georgetown University Hospital. He is board-certified in emergency medicine and is a fellow of the American College of Emergency Physicians.

Additionally, Dr. Smith is the Director of the ER One Institute and the co-founder of Project ER One, MedStar Washington Hospital Center's initiative to develop the design concepts, features, and specifications for an all-risks ready emergency care facility, one that is optimized to manage the medical consequences of terrorism and mass casualty incidents. He is the co-creator of MedStar Health's innovative Azyxxi clinical information system, which was acquired and is being commercialized as Microsoft Amalga. Dr. Smith has authored numerous journal articles and presentations on emergency medicine and two textbooks in the field.

Research Interests

Dr. Smith's research interests include

  • Emergency medicine
  • Disaster preparedness and coping effectively with emerging diseases and terrorist events, including chemical, biological, radiological/nuclear, and explosive incidents
  • Healthcare innovations, including products & processes
  • Medical informatics and the effective application of information technology to clinical care

Learn more about MedStar's Innovation Institute (MI2).

Selected Publications

Tobach E, Smith M, Rose G, Richter D. A table for rank sum multiply paired comparisons. Technometrics 9:561-67, 1967.

Perkel D, Gerstein G, Smith M, Tatton W. Nerve impulse patterns:a quantitative display technique for three neurons. Brain Research 100:271-96, 1975.

Perkel D, Smith M. A computer program for simulating a network of interesting neurons II: programming aspects. Computers and Biomedical Research 9:45-67, 1976.

Smith M. Applications of a pocket computer to clinical medicine. Yale University School of Medicine Thesis Project, 1977.

Smith M. Solvent Toxicity: isopropanol, methanol and ethylene glycol. Ear, Nose and Throat 62:13-26, 1983.

Smith M. Disaster Communications. Chapter in FEMA/ACEP course book: Disaster Management and Planning for Emergency Physicians, 1983.

Shesser R, Smith M. Oral Emergencies. Topics in Emergency Medicine 6:48-65, 1984.

Shesser R, Smith M, Ellis P, Brett S, Ott J. Recreational softball injuries. Am J Emerg Med 3:199-202, 1985.

Shesser R, Smith M, Kline P, Rosenthal R, Turbiak T, Chen H. A cost-effective emergency medicine clerkship. J Med Educ 60:288-292, 1985.

Shesser R, Smith M, Kline P, Turbiak T, Rosenthal R, Chen H, Walls R. A student emergency medicine clerkship which utilizes new information technologies. J Emerg Med 2:455-461, 1985.

Smith M. Book Review of Color Atlas of Accidents and Emergencies. The New Physician. February 1985.

Shesser R, Smith M. Seizures in psychiatric patients. American Journal of Emergency Medicine 3:451-455, 1985.

Smith M, et al. Editorial Board Roundtable. Primary Care Emergency Decisions 1(1):7-12, 1985.

Smith M, Shesser R. Oral Emergencies in ENT Emergencies, T Stair (ed), Aspen Publications, Rockville, Maryland, 1985.

Kline P, Shesser R, Smith M, et al. A comparison of a videotape instructional program >with a traditional lecture series for medical student emergency medicine teaching. Annals of Emergency Medicine 15:16-18, 1986.

Shesser R, Smith M. Conservative correction of hyponatremia (letter). Am J Emerg Med 4:296, 1986.

Shesser R, Smith M, Adams S, Walls R, Paxton M. The Effectiveness of an Organized Emergency Department Follow-up System. Annals of Emergency Medicine 15:911-915, 1986.

O'Leary M, Smith M. Anaphylaxis to Oral Penicillin. Am J Emerg Med 4:241-247, 1986.

Rosenthal RE, Smith J, Walls R, Chen H, Kline P, Shesser R, Smith M. Stab wounds to the abdomen: failure of blunt probing to predict peritoneal penetration. Ann Emerg Med 16:172-174, 1987.

Smith M, Eisenberg M. Thrombolytic therapy for myocardial infarction (editorial). Ann Emerg Med 16:592-593, 1987.

O'Leary M, Smith M, Druy E. Diagnostic and therapeutic approach to axillary-subclavian vein thrombosis. Ann Emerg Med 16:889-893, 1987.

Eisenberg M, Smith M. Thrombolytic therapy for myocardial infarction: Pivotal role for emergency medicine. Ann Emerg Med 16:592-593, 1987.

Smith M. The man with the round face. J Emerg Med 5:421-422, 1987.

O'Leary MR, Smith M, Olmsted WW, Curtis DJ. Physician assessments of practice patterns in emergency department radiograph interpretation. Ann Emerg Med 17:1019-1023, 1988.

Smith MS, Shesser RS. Emergency care of the VIP patient. NE J Emerg Med 319:1421-1423, 1988.

Hertzman M, Werner M, Kasdan P, Pauley CJ, Neubauer-Rossi A, Rosenthal R, Smith M. Symptomatological Manifestations of Phencyclidine (PCP) at Low Serum Levels. AMERSA Substance Abuse 9(4): 205-215, Fall 1988.

O'Leary MR, Smith MS, O'Leary DS, Olmsted WW, Curtis DI, Grolieu G, Mabey B. Application of clinical indicators in the emergency department. JAMA 262:3444-7, 1989.

Seneff M, Scott J, Friedman B, Smith M. Acute theophylline toxicity and the use of esmolol to reverse cardiovascular Instability. Ann Emerg Med 19:6:671-673, 1990.

Burns RB, Stoy DB, Feied CF, Nash E, Smith M. Cholesterol screening in the emergency department. J Gen Int Med 6: 210-215, 1991.

Tsakonis JS, Shesser RF, Rosenthal R, Bittar GD, Smith M, Wasserman AG. Safety of immediate treadmill testing in selected emergency department patients with chest pain a preliminary report. Am J Emerg Med, 9: 557-9, 1991.

Pigman E, Smith M. Prehospital prophylactic lidocaine for uncomplicated acute myocardial infarction (Editorial). J Emerg Med, 11:753-758, 1993.

Shesser R, Smith M. The chest pain emergency department and the outpatient chest pain evaluation center: Revolution or evolution? Ann Emerg Med 23:2, 334-341, 1993.

Smith MS. The development of the specialty of emergency medicine in the United States. Reanimation Urgences 2:127-133, 1993.

Hallagan, LF, Smith, MS. Profound atelectasis following alkaline corrosive airway injury. J Emerg Med 12:23-5, 1994.

Scott J, Smith MS, Sanford SM, Shesser RF, Rosenthal RE, Smith JP, Feied CF, Ghezzi KT, Hunt DM. Effectiveness of transnasal butorphanol for the treatment of musculoskeletal pain. Am J Emerg Med 12:469-71, 1994.

Shesser RF, Smith M. The chest pain emergency department and the outpatient chest pain evaluation center: revolution or evolution? Ann Emerg Med 12: 334-41, 1994.

Pelucio MT, Rothenhaus T, Smith M, Ward DJ. Fatal pancreatitis as a complication of therapy for HIV infection. J Emerg Med 13:633-7, 1995.

Hedges JS, Gibler WB, Young GP, Hoekstra JW, Slovis C, Aghababian R, Smith M. Multicenter Study of Creatine Kinase-MB use: Effect on chest pain clinical decision making. Academic Emerg Med 3: 7-15, 1996.

Smith MS, Feied C. The next-generation emergency department. Ann Emerg Med, 32: 65-74, 1998.>

Cannon CP, Smith MS. Advances in Alliteration in Acute Myocardial Infarction: From "Time to Treatment" to "Onset to Opening", 6: 5-7, 1998.

Feied CF, Smith MS, Handler JA, Kanhouwa M. Emergency medicine can play a leadership role in enterprise-wide clinical information systems. Ann Emerg Med 35: 162-7, 2000.

Smith MS. Applying information technology to the problem of acute myocardial infarction access to care, diagnosis, and evaluation, report of a symposium. Ann Emergency Med 38:286-92, 2001

Barthell EN, Cordell WH, Moorhead JC, Handler J, Feied C, Smith MS, Cochrane DG, Felton CW, Collins MA. The frontlines of medicine project: a proposal for standardized communication of emergency department data for public health uses including syndromic surveillance for biological and chemical terrorism. Ann Emerg Med 39:422-29, 2002.

Feied C, Smith M, Handler J. Keynote Address: Medical Informatics and Emergency Medicine. Academic Emerg Med 11:1118-26, 2004.

Handler J, Feied C, Coonan K, Vozenilek J, Gillam M, Peacock PR Jr., Sinert R, Smith M. Computerized Physician Order Entry and Online Decision Support. Academic Emerg Med 11:1135-41, 2004.

Feied C, Handler J, Smith M, Gillam M, Kanhouwa M, Rothenhaus T, Conover K, Shannon T. Clinical Information Systems: Instant Ubiquitous Clinical Data for Error Reduction and Improved Clinical Outcomes. Academic Emerg Med 11:1162-9, 2004.

Smith M, Feied C, Gillam M, Wachs J, Stern H, Handler J: A Real-Time Gesture Interface for Hands-Free Control of Electronic Medical Records. Annual Symposium Proceedings 920, 2006.

Smith M, Feied C, Gillam M, Birchfield C, Handler J. Automated Patient Facial Image Capture to Reduce Medical Error. Annual Symposium Proceedings 929, 2006.

Smith M, Feied C, Gillam M, Handler J. Improving a UMLS Based Allergy List for Use in Live Electronic Medical Record Systems. Annual Symposium Proceedings 942,2006.

Kartoun, U, Smith M, Feied C, Gillam M, Handler J, Stern H. Use of Medical Robotics in Biothreat Situations. Annual Symposium Proceedings 976, 2006.

Smith M, Feied C, Gillam M, Handler J. Automated Medical Image Library Creation for Education. Annual Symposium Proceedings 1103, 2006.

Shannon T, Feied C, Smith M, Handler J, Gillam M. Wireless Handheld Computers and Voluntary Utilization of Computerized Prescribing Systems in the Emergency Department. J Emerg Med 31:309-15, 2006.

Plaisant C, Lam S, Shneiderman B, Smith MS, Roseman D, Marchand G, Gillam M, Feied C, Handler J, Rappaport H. Searching electronic health records for temporal patterns in patient histories: a case study with Microsoft Amalga. AMIA Annu Symp Proc. Nov 6:601-5, 2008.

  • Research Areas
  • Critical Care/Emergency Medicine
  • Health Services/Quality/Outcomes