Jeffrey A. Toretsky, MD| Pediatric Hematology | MedStar Health
About me
Jeffrey A. Toretsky, MD, serves as chief of MedStar Georgetown University Hospital’s Division of Pediatric, Adolescent, and Young Adult Hematology/Oncology. Dr. Toretsky is an internationally recognized expert in sarcomas in children, adolescents, and young adults. He is the principal investigator and director of the NIH-funded Molecular Oncology Program at the Georgetown Lombardi Comprehensive Cancer Center and co-leads a regional multidisciplinary sarcoma clinic.
Dr. Toretsky and a multidisciplinary team are engaged with all aspects of pediatric hematology/oncology from diagnosis through survivorship. His laboratory is pursuing new and targeted therapies for Ewing sarcoma, including a new medication for Ewing sarcoma currently in phase 1 clinical trials.
Dr. Toretsky’s areas of clinical expertise include:
- Sarcoma
- Diagnosis and treatment of rare tumors
- Benign and malignant hematology
- Brain tumors
- Other childhood, adolescent and young adult tumors
Learn more about Toretsky Lab here.
Clinical areas of focus
- Anemia
- Bone Cancer
- Bone Marrow Biopsy
- Bone Marrow Biopsy And Aspiration
- Liposarcoma
- Mesothelioma
- Musculoskeletal Tumor
- Nonautologous Red Blood Cells Transfusion
- Ovarian Germ Cell Tumor
- Sickle Cell Disease
- Thalassemia
- Tumor Immunohistochemistry
Conditions and procedures
Conditions I treat
- Adrenal Tumor
- Anemia
- Aplastic Anemia
- Benign Neoplasm Of Bone And Articular Cartilage
- Bone Cancer
- Bone Discontinuity
- Bone Marrow Transplant Graft Failure
- Bone Sarcoma
- Brain Tumor
- Cancer Of The Blood
- Chronic Eosinophilic Leukemia
- Disorders Involving The Immune Mechanism
- Family History Of Malignant Neoplasm
- Gallbladder Disease
- Hodgkin Disease
- Immunoglobulin Deficiency
- Leukocytosis (HIGH WHITE BLOOD CELL COUNT)
- Liposarcoma
- Liver Cancer
- Malignant Neoplasm Of Bone And Articular Cartilage Of Limbs
- Malignant Neoplasm Of Eye And Adnexa
- Mesothelioma
- Multiple Myeloma
- Musculoskeletal Tumor
- Ovarian Germ Cell Tumor
- Secondary Lymph Node Cancer
- Sickle
- Sickle Cell Anemia
- Sickle Cell Disease
- Skull Base Tumor
- Soft Tissue Sarcoma
- Testicular Cancer
- Thalassemia
- Thrombocytopenia
- Thymus Gland Tumors
- Thyroid Cancer
- Wilms Tumor
Procedures I perform
- Antineoplastic Injection
- Blood Banking
- Blood Transfusion
- Bone Marrow Aspiration
- Bone Marrow Biopsy
- Bone Marrow Biopsy And Aspiration
- Chemotherapy Administration
- Ear Tube Insertion
- Iliac Bone Marrow Extraction
- Immunotherapy
- Internal Jugular Central Line Placement
- Introduction Of Antineoplastic
- Lumbar Puncture
- Nonautologous Red Blood Cells Transfusion
- Pathology Consultation
- Radiation Therapy
- Removal Of Central Venous Access Device
- Tumor Immunohistochemistry
- Venous Access Device Irrigation
- Venous Blood Collection
Videos
Awards
- Fellow, National Academy of Inventors, 2018
- Outstanding Faculty Entrepreneur in Medical Science, Georgetown Business School, 2012
- Georgetown University Medical Center Convocation Honoree for Outstanding Research, 2009
- National Academies Keck Futures Initiatives Conference, 2009
- Georgetown University Medical Center Convocation Honoree, 2008
- Burroughs Wellcome Clinical Scientist Award in Translational Research, 2008
News and publications
- Anderson ND, de Borja R, Young MD, Fuligni F, Rosic A, Roberts ND, Hajjar S, Layeghifard M, Novokmet A, Kowalski PE, Anaka M, Davidson S, Zarrei M, Id Said B, Schreiner LC, Marchand R, Sitter J, Gokgoz N, Brunga L, Graham GT, Fullam A, Pillay N, Toretsky JA, Yoshida A, Shibata T, Metzler M, Somers GR, Scherer SW, Flanagan AM, Campbell PJ, Schiffman JD, Shago M, Alexandrov LB, Wunder JS, Andrulis IL, Malkin D, Behjati S, Shlien A. Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors. Science. 2018 Aug 31;361(6405). PubMed PMID: 30166462. Pubmed Central PMCID: 6176908.
- Gorthi A, Romero JC, Loranc E, Cao L, Lawrence LA, Goodale E, Iniguez AB, Bernard X, Masamsetti VP, Roston S, Lawlor ER, Toretsky JA, Stegmaier K, Lessnick SL, Chen Y, Bishop AJR. Author Correction: EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma. Nature. 2018 Jul;559(7715):E11. PubMed PMID: 29950716.
- Smith-Guzman NE, Toretsky JA, Tsai J, Cooke RG. A probable primary malignant bone tumor in a pre-Columbian human humerus from Cerro Brujo, Bocas del Toro, Panama. International journal of paleopathology. 2018 Jun;21:138-46. PubMed PMID: 29778411.
- Selvanathan SP, Graham GT, Grego AR, Baker TM, Hogg JR, Simpson M, Batish M, Crompton B, Stegmaier K, Tomazou EM, Kovar H, Uren A, Toretsky JA. EWS-FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex. Nucleic acids research. 2019 Oct 10;47(18):9619-36. PubMed PMID: 31392992. Pubmed Central PMCID: 6765149.
- Spriano F, Chung EYL, Gaudio E, Tarantelli C, Cascione L, Napoli S, Jessen K, Carrassa L, Priebe V, Sartori G, Graham G, Selvanathan SP, Cavalli A, Rinaldi A, Kwee I, Testoni M, Genini D, Ye BH, Zucca E, Stathis A, Lannutti B, Toretsky JA, Bertoni F. The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Aug 15;25(16):5167-76. PubMed PMID: 31182435.
- Ko, K., Kitani, T., Harris, B. T., Anaizi, A. N., Solomon, D., Perry, A., Toretsky, J. and Ozdemirli, M. A novel PARD3B-NUTM1 fusion in an aggressive primary CNS embryonal tumor in a young adult. Acta Neuropathol Commun. 2020 Jul 17;8(1):112. doi: 10.1186/s40478-020-00991-w.
- Pecora, A., Halpern, S., Weber, M., Paleoudis, E. G., Panush, D., Patterson, F. and Toretsky, J. Rapid and Complete Response to Combination Anti-CTLA-4 and Anti-PD-1 Checkpoint Inhibitor Therapy in a Patient With Stage IV Refractory End-stage Epithelioid Sarcoma: A Case Report. J Immunother. 2020 Nov/Dec;43(9):286-290. doi: 10.1097/CJI.0000000000000332.
- J. Dong, R. Y. Zhang, N. Sun, J. Hu, M. D. Smalley, A. Zhou, Y. Hua, W. Rothermich, M. Chen, J. Chen, J. Ye, P.-C. Teng, D. Qi, J. A. Toretsky, J. S. Tomlinson, M. Li, P. S. Weiss, S. J. Jonas, N. Federman, L. Wu, M. Zhao,* H.-R. Tseng,* Y. Zhu. Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma‐Derived Extracellular Vesicles for Downstream Functional Studies. Advanced Functional Materials. 2020 September 13; https://doi.org/10.1002/adfm.202003237.
For complete list: http://www.ncbi.nlm.nih.gov/pubmed/?term=Toretsky+J