Jeffrey A. Toretsky, MD| Pediatric Hematology Oncology, Pediatric Hematology | MedStar Health

Jeffrey A. Toretsky, MD
Provider is directly employed by MedStar Health

Specialities: Pediatric Hematology Oncology, Pediatric Hematology, Pediatric Medical Oncology

Languages: English


About me

Jeffrey A. Toretsky, MD, serves as chief of MedStar Georgetown University Hospital’s Division of Pediatric, Adolescent, and Young Adult Hematology/Oncology. Dr. Toretsky is an internationally recognized expert in sarcomas in children, adolescents, and young adults. He is the principal investigator and director of the NIH-funded Molecular Oncology Program at MedStar Georgetown University Hospital’s Lombardi Comprehensive Cancer Center and co-leads a regional multidisciplinary sarcoma clinic.

Dr. Toretsky and a multidisciplinary team are engaged with all aspects of pediatric hematology/oncology from diagnosis through survivorship. His laboratory is pursuing new and targeted therapies for Ewing sarcoma, including a new medication for Ewing sarcoma currently in phase 1 clinical trials.

Dr. Toretsky’s areas of clinical expertise include:

  • Sarcoma
  • Diagnosis and treatment of rare tumors
  • Benign and malignant hematology
  • Brain tumors
  • Other childhood, adolescent and young adult tumors

Learn more about Toretsky Labhere.

Clinical areas of focus

  • Biological Targeted Therapy
  • Bone Sarcoma
  • Cancer Chemotherapy
  • Cancer Survivor
  • Ewings Sarcoma
  • Germ Cell Tumor
  • Leukemia
  • Lymphoma
  • Musculoskeletal Tumor
  • Osteosarcoma
  • Rhabdomyosarcoma
  • Sarcoma
  • Sickle Cell Disease
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Conditions and procedures

Conditions I treat

  • Abdominal Pain
  • Acute Lymphoblastic Leukemia (ALL)
  • Acute Myelogenous Leukemia (AML)
  • Adamantinoma
  • Adverse Effects To Anticoagulants
  • Alveolar Soft Part Sarcoma
  • Anaplastic Cancer Of Thyroid
  • Anemia
  • Anemia Of Chronic Disease
  • Angiomatoid Fibrous Histiocytoma
  • Angiosarcoma
  • Antithrombin Deficiency
  • Aplastic Anemia
  • Askin's Tumor
  • Atypical Lipomatous Tumor
  • B12 Deficiency Anemia
  • Back Pain
  • Beckwith Wiedemann Syndrome
  • Bleeding Disorder
  • Blood Cancer
  • Blood Clotting Disorder
  • Blood Disorders
  • Bone Cyst
  • Bone Marrow Disorders
  • Bone Sarcoma
  • Bone Tumor
  • Brain Neoplasms
  • Burkitt Lymphoma
  • Cancer
  • Cancer Pain
  • Cancer Related Fatigue
  • Cancer Survivor
  • Cardiac Sarcoma
  • Cardio Oncology
  • Cervical Teratoma
  • Chondrosarcoma
  • Chronic Fatigue
  • Chronic Pain
  • Clear Cell Sarcoma
  • Cloves Syndrome
  • Composite Hemangioendothelioma
  • Cooley Anemia
  • Cryoglobulinemia
  • Delayed Menarche
  • Delayed Puberty
  • Dermatofibrosarcoma Protruberans
  • Desmoid Tumors
  • Desmoplastic Small Cell Tumor
  • Desmoplastic Small Round Cell Tumors
  • Diamond Blackfan Anemia
  • Diffuse Intrinsic Pontine Glioma (DIPG)
  • Dyskeratosis Congenita
  • Dysmenorrhea
  • Ectomesenchymoma
  • Egfr Mutation
  • Endocrine Complications Of Cancer Therapy
  • Epithelioid Hemangioendothelioma
  • Epithelioid Sarcoma
  • Ewings Sarcoma
  • Extrarenal Rhabdoid Tumor
  • Extraskeletal Mesenchymal Chondrosarcoma
  • Extraskeletal Myxoid Chondrosarcoma
  • Extraskeletal Osteosarcoma
  • Factor Eight Disorder
  • Factor Nine Deficiency
  • Factor V Leiden
  • Familial Aplastic Anemia
  • Fanconi Anemia
  • Fibrosarcoma
  • Fibrosarcoma Of The Head & Neck
  • Follicular Cancer Of Thyroid
  • Germ Cell Tumor
  • Germinoma
  • Giant Cell Tumor Of The Bone
  • Glioma
  • Glucose 6 Phosphate Dehydrogenase Deficiency
  • Granulation Cell Sarcoma
  • Head And Neck Tumors
  • Headache
  • Hemochromatosis
  • Hemoglobinopathies
  • Hemolytic Anemia
  • Hemolytic Disease Of The Fetus
  • Hemolytic Uremic Syndrome
  • Hemophilia
  • Heparin Induced Thrombocytopenia
  • Hereditary Cancer Risk
  • Hereditary Spherocytosis
  • Histiocytosis
  • Hypercoagulable State
  • Hypogammaglobulinemia
  • Idiopathic Thrombocytopenic Purpura
  • Inflammatory Myofibroblastic Tumor
  • Intimal Sarcoma
  • Iron Deficiency Anemia
  • Irregular Menstruation
  • Juvenile Myelomonocytic Leukemia
  • Kasabach Merritt Phenomenon (KMP)
  • Langerhans Cell Histiocytosis
  • Leiomyosarcoma
  • Leukemia
  • Leukopenia
  • Li Fraumeni Syndrome
  • Liposarcoma
  • Low Grade Fibromyxoid Sarcoma
  • Lymphangiosarcoma
  • Lymphoma
  • Lymphopenia
  • Malignant Fibrous Histiocytoma (MFH)
  • Malignant Glomus Tumor
  • Malignant Granular Cell Tumor
  • Malignant Mesenchymoma
  • Malignant Peripheral Nerve Sheath Tumor
  • Malignant Primitive Neuroectodermal Tumor (PNET)
  • Malignant Rhabdoid Tumor
  • Malignant Schwannoma
  • Malignant Tenosynovial Giant Cell Tumor
  • Malnutrition
  • Medullary Cancer Of Thyroid
  • Menorrhagia
  • Menstrual Disorders
  • Musculoskeletal Tumor
  • Myelodysplastic Syndrome
  • Myeloproliferative Diseases
  • Myoepithelioma/Mixed Tumor Of Soft Tissue
  • Myofibroblastic Sarcoma
  • Myxofibrosarcoma
  • Myxoinflammatory Fibroblastic Sarcoma
  • Nephroblastoma
  • Neuroblastoma
  • Neuroectodermal Tumor
  • Neurofibrosarcoma
  • Neuronal Glial Tumors
  • Neutropenia
  • Non Hodgkin Lymphoma
  • Odontogenic Tumors
  • Optic Pathway Glioma
  • Oral Complications Of Cancer
  • Oral Lesions
  • Osteosarcoma
  • Pancytopenia
  • Papillary Cancer Of Thyroid
  • Paroxysmal Nocturnal Hemoglobinuria
  • Pecoma
  • Pediatric Cancer
  • Pelvic Pain
  • Pernicious Anemia
  • Petechiae
  • Peutz Jeghers Syndrome
  • Plasma Cell Dyscrasia
  • Pleomorphic Sarcoma
  • Pleomorphic Xanthoastrocytomas
  • Polycystic Ovary Syndrome
  • Polycythemia
  • Porphyria
  • Primary Systemic Amyloidosis
  • Pulmonary Metastases
  • Pure Red Cell Aplasia
  • Purpura
  • Radiation Associated Sarcomas
  • Retiform Hemangioendothelioma
  • Retinoblastoma
  • Retroperitoneal Mass
  • Retroperitoneal Sarcoma
  • Rh Incompatibility
  • Rhabdomyosarcoma
  • Sacrococcygeal Teratoma
  • Sarcoma
  • Sarcoma Botryoides
  • Sarcoma Of The Lung
  • Scoliosis
  • Secondary Polycythemia
  • Severe Congenital Neutropenia
  • Sickle Cell Disease
  • Side Effects Of Cancer Treatment
  • Solitary Fibrous Tumor
  • Spindle Cell Sarcoma
  • Splenic Sequestration
  • Splenomegaly
  • Sports Related Injury
  • Submucosal Tumors
  • Sweat Gland Carcinoma
  • Synovial Sarcoma
  • Tectal Glioma
  • Teratogen Exposure
  • Thalassemia
  • Thrombocytopenia
  • Thrombocytosis
  • Thrombophilia
  • Thrombotic Thrombocytopenic Purpura
  • Tracheal Cancer
  • Unclassified Sarcoma
  • Undifferentiated Pleomorphic Sarcoma
  • Undifferentiated Sarcoma
  • Venous Occlusive Crisis
  • Von Willebrand Disease
  • Weight Loss
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Procedures I perform

  • Adjuvant Chemotherapy
  • Biological Targeted Therapy
  • Brain Cancer Genomics
  • Breast Cancer Immunotherapy
  • Cancer Chemotherapy
  • Cancer Genomics
  • Cancer Immunotherapy
  • Cancer Rehabilitation
  • Chemoradiation
  • Early Detection Of Cancer
  • Gastrointestinal (GI) Cancer Genomics
  • Genitourinary Cancer Genomics
  • Head And Neck Cancer Genomics
  • Leukemia Genomics
  • Liver Cancer Genomics
  • Lymphoma Genomics
  • Melanoma Genomics
  • Pancreatic Cancer Genomics
  • Pediatric Stem Cell Collection For Transplant
  • Radionuclide Therapy
  • Renal Cancer Genomics
  • Sarcoma Genomics
  • Skin Cancer Genomics
  • Thyroid Cancer Genomics
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Practice locations

Distance from Change LocationEnter your Location

3800 Reservoir Road Northwest
Lombardi Cancer Center
Washington, DC, 20007


Fax 202-444-8817

Get Directions

miles away

Fax 202-444-8817


MedStar Medical Group accepts most major health insurance plans. If you are uncertain as to whether your individual health insurance plan is accepted at MedStar Medical Group, please call your insurance company.

  • List of insurance plans we accept
    • Aetna Elect Choice/ EPO (Aetna Health Fund) Innovation Health: Network Only Plus
    • Aetna Quality Point of Service (POS)
    • Aetna USAccess (POS)
    • Aetna Student Health Insurance
    • Aetna Medicare Advantage HMO & PPO Plans
    • CFBCBS BlueChoice HMO
    • CFBCBS Blue Choice Opt Out Plus Open Access (POS)
    • CFBCBS Maryland Point of Service Plan (MPOS)
    • CFBCBS Federal Employee Program (Std. & Basic PPO)
    • CFBCBS Maryland Indemnity or PPO
    • CFBCBS (NCA) Indemnity
    • CIGNA HMO & Network (HMO)
    • CIGNA POS/Network POS
    • Great-West Healthcare POS/CIGNA
    • CIGNA Indemnity
    • Coventry Health Care of Virginia
    • Coventry of Delaware HMO/PPO
    • First Health PPO
    • Tricare Prime
    • Tricare Standard
    • Tricare Extra (Indemnity)
    • Tricare for Life (Medicare Supplemental Plan)
    • MedStar Family Choice - Maryland Health Choice
    • MedStar Select (MedStar Associates' Plan)
    • MedStar Medicare Choice
    • United Healthcare Select HMO - EPO/NPP
    • United Healthcare Select Plus (POS)
    • United Healthcare Choice Plus
    • United Student Resources
    • M.D. IPA (HMO)
    • M.D. IPA Preferred (POS)
    • Optimum Choice Preferred (POS) & OCI Direct (HMO)
    • Mamsi Life & Health (Indem./PPO)
    • Aetna Worker's Compensation Network
    • Coventry Health Care National Network PPO
    • Private Health Care Systems (PHCS) (PPO)
    • United Healthcare Options (PPO) (includes Empire PPO, GEHA, Compass Rose)
    • OneNet PPO, Inc.
    • United Healthcare Choice
    • United Healthcare Core Essential (HMO)
    • Optimum Choice
    • United Healthcare Navigate
    • United Healthcare Compass (HMO)
    • CIGNA HMO Open Access (OA)
    • Network OA
    • POS OA & OA Plus
    • PPO and PPO Plus
    • Choice Fund PPO
    • CFBSBC Blue Preferred PPO
    • HealthyBlue PPO
    • CFBCBS Blue Choice Opt Out Open Access
    • BlueChoice Open Access
    • Blue Choice Advantage & Healthy Blue (HMO, POS)
    • Aetna Traditional Choice (PPO)
    • Innovation Health: Indemnity
    • Aetna Open Choice (PPO)
    • Innovation Health: PPO
    • Aetna Managed Choice (POS)
    • Innovation Health: POS Plus
    • Aetna Elect Choice/ Open Access (POS)
    • Innovation Health: Open Network Only Plus
    • Aetna HMO-Open Access/Select OA/HealthFund/Health Network Option OA
    • Innovation Health: POS
    • Open HMO
    • Opoen HMO Option
    • Open EPO Plus
    • Aetna Managed Choice Open Access (POS)
    • Choice POS & Choice POS II
    • Innovation Health: Open POS Plus
    • Open POS II
    • Aetna HMO
    • Select HMO/HealthFund/Health Network
    • Aetna Innovations: HMO & EPO Plus



Board Certification: American Board of Pediatrics, Pediatric Hematology-Oncology

Fellowship Program: National Cancer Institute (1997)

Residency Program: Medical College of Virginia-VCU (1991)

Internship Program: Duke University Medical Center (1989)

Medical School: University of Minnesota Medical School (1988)


  • Fellow, National Academy of Inventors, 2018
  • Outstanding Faculty Entrepreneur in Medical Science, Georgetown Business School, 2012
  • Georgetown University Medical Center Convocation Honoree for Outstanding Research, 2009
  • National Academies Keck Futures Initiatives Conference, 2009
  • Georgetown University Medical Center Convocation Honoree, 2008
  • Burroughs Wellcome Clinical Scientist Award in Translational Research, 2008

News and publications

  1. Anderson ND, de Borja R, Young MD, Fuligni F, Rosic A, Roberts ND, Hajjar S, Layeghifard M, Novokmet A, Kowalski PE, Anaka M, Davidson S, Zarrei M, Id Said B, Schreiner LC, Marchand R, Sitter J, Gokgoz N, Brunga L, Graham GT, Fullam A, Pillay N, Toretsky JA, Yoshida A, Shibata T, Metzler M, Somers GR, Scherer SW, Flanagan AM, Campbell PJ, Schiffman JD, Shago M, Alexandrov LB, Wunder JS, Andrulis IL, Malkin D, Behjati S, Shlien A. Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors. Science. 2018 Aug 31;361(6405). PubMed PMID: 30166462. Pubmed Central PMCID: 6176908.

  2. Gorthi A, Romero JC, Loranc E, Cao L, Lawrence LA, Goodale E, Iniguez AB, Bernard X, Masamsetti VP, Roston S, Lawlor ER, Toretsky JA, Stegmaier K, Lessnick SL, Chen Y, Bishop AJR. Author Correction: EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma. Nature. 2018 Jul;559(7715):E11. PubMed PMID: 29950716.

  3. Smith-Guzman NE, Toretsky JA, Tsai J, Cooke RG. A probable primary malignant bone tumor in a pre-Columbian human humerus from Cerro Brujo, Bocas del Toro, Panama. International journal of paleopathology. 2018 Jun;21:138-46. PubMed PMID: 29778411.

  4. Selvanathan SP, Graham GT, Grego AR, Baker TM, Hogg JR, Simpson M, Batish M, Crompton B, Stegmaier K, Tomazou EM, Kovar H, Uren A, Toretsky JA. EWS-FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex. Nucleic acids research. 2019 Oct 10;47(18):9619-36. PubMed PMID: 31392992. Pubmed Central PMCID: 6765149.

  5. Spriano F, Chung EYL, Gaudio E, Tarantelli C, Cascione L, Napoli S, Jessen K, Carrassa L, Priebe V, Sartori G, Graham G, Selvanathan SP, Cavalli A, Rinaldi A, Kwee I, Testoni M, Genini D, Ye BH, Zucca E, Stathis A, Lannutti B, Toretsky JA, Bertoni F. The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Aug 15;25(16):5167-76. PubMed PMID: 31182435.

  6. Ko, K., Kitani, T., Harris, B. T., Anaizi, A. N., Solomon, D., Perry, A., Toretsky, J. and Ozdemirli, M. A novel PARD3B-NUTM1 fusion in an aggressive primary CNS embryonal tumor in a young adult. Acta Neuropathol Commun. 2020 Jul 17;8(1):112. doi: 10.1186/s40478-020-00991-w.

  7. Pecora, A., Halpern, S., Weber, M., Paleoudis, E. G., Panush, D., Patterson, F. and Toretsky, J. Rapid and Complete Response to Combination Anti-CTLA-4 and Anti-PD-1 Checkpoint Inhibitor Therapy in a Patient With Stage IV Refractory End-stage Epithelioid Sarcoma: A Case Report. J Immunother. 2020 Nov/Dec;43(9):286-290. doi: 10.1097/CJI.0000000000000332.

  8. J. Dong, R. Y. Zhang, N. Sun, J. Hu, M. D. Smalley, A. Zhou, Y. Hua, W. Rothermich, M. Chen, J. Chen, J. Ye, P.-C. Teng, D. Qi, J. A. Toretsky, J. S. Tomlinson, M. Li, P. S. Weiss, S. J. Jonas, N. Federman, L. Wu, M. Zhao,* H.-R. Tseng,* Y. Zhu. Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma‐Derived Extracellular Vesicles for Downstream Functional Studies. Advanced Functional Materials. 2020 September 13;

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