Dr. Jonathan S. Grinstein, MD

Dr. Jonathan S. Grinstein, MD

Dr. Jonathan S. Grinstein, MD

Languages: English
Fax: 2028778032

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Specialties
  • Heart Failure and Transplantation Cardiology
Conditions I Treat
  • advanced heart failure
  • alcoholic cardiomyopathy
  • arrhythmogenic right ventricular dysplasia
  • beriberi
  • cardiac amyloid
  • Show All
Procedures I Perform
  • cardiomems
  • chronic inotropic therapy
  • circulatory assist devices
  • heart biopsy
  • heart transplant
  • Show All
About the Provider

Jonathan Grinstein, MD, is an advanced heart failure physician at the Advanced Heart Failure Center at MedStar Washington Hospital Center. He is an Assistant Professor of Medicine at Georgetown University School of Medicine and a member of the Alpha Omega Alpha Medical Society and the Gold Humanism Honor Society.

As a specialist in the field of cardiovascular disease and advanced heart failure, Dr. Grinstein treats patients through the use of left ventricular assist devices (LVADs), long-term IV medications or continuous infusion pump medications, and heart transplantation.

Dr. Grinstein received his medical degree from the University of Chicago. He then joined Brigham and Women’s Hospital, associated with Harvard Medical School, for internship and residency training in internal medicine. Finally, he returned to the University of Chicago for a three-year fellowship in cardiology followed by specialty training in advanced heart failure.

Dr. Grinstein participates in novel research involving LVADs. In lieu of a physical examination or an invasive right heart catheterization procedure, Dr. Grinstein has researched, perfected, and currently utilizes an echocardiographic and computed tomography techniques to noninvasively monitor the pressure, volume and flow inside the heart of individuals with an implanted LVAD. This technique allows cardiologists to analyze how well a patient is responding to the device and make necessary adjustments in real time. He has also conducted research to develop a “smart” LVAD that can intuitively adjust its speed based on the physiological needs of the patient.

Dr. Grinstein is passionate about continuing groundbreaking research at MedStar Washington Hospital Center’s Heart and Vascular Institute.

Philosophy of Care

“Every patient, no matter how sick, deserves the opportunity to improve his/her quality of life and to extend his/her life with advanced medical techniques. I went into the cardiovascular field, and more specifically I was drawn to advanced heart failure, because I want to help people at their time of most need.

“I’m truly a believer in research. I’m constantly trying to evolve my philosophy and practice to incorporate newer state-of-the-art techniques that significantly improve patient outcomes.

“I care for my patients deeply. Whether it’s extending life, improving quality of life, or transitioning to end of life in a more compassionate way for those in end-stage heart failure, we can provide care for all patients we meet.”

Education
  • Fellowship Program: University of Chicago Medical Center (2017)
  • Fellowship Program: University of Chicago Medical Center (2016)
  • Residency Program: Brigham and Women's Hospital (2013)
  • Medical School: University of Chicago Pritzker School of Medicine (2010)
  • Board Certification: American Board of Internal Medicine, Cardiovascular Disease
  • Board Certification: American Board of Internal Medicine, Advanced Heart Failure and Transplant Cardiology
  • Board Certification: American Board of Internal Medicine, Internal Medicine
Publications
Original Research

Grinstein J, Imamura T, Kruse E, Kalantari S, Rodgers D, Adatya S, Sayer G, Kim GH, Sarswat N, Raihkelkar J, Ota T, Jeevanandam V, Burkhoff D, Lang R, Uriel N. "Echocardiographic Predictors of Hemodynamics in Patients Supported with Left Ventricular Assist Devices." Journal of Cardiac Failure (2018)

Grinstein J, Rodgers D, Kalantari S, Sayer G, Kim GH, Sarswat N, Adatya S, Ota T, Jeevanandam, Burkhoff, D , Uriel N. "HVAD Waveform Analysis as a Non-Invasive Marker of Pulmonary Capillary Wedge Pressure: A First Step towards the Development of a Smart Left Ventricular Assist Device." ASAIO Journal (2018)

Tehrani DM, Adatya S, Grinstein J, Rodgers D, Sarswat N, Kim GH, Raikhelkar J, Sayer G, Uriel N. "Impact of Cardiac Resynchronization Therapy on Left Ventricular Unloading in Patients with Implanted Left Ventricular Assist Devices." ASAIO Journal (2018)

Grinstein J, Kruse E, Sayer G, Kim GH, Raikhelkar J, Kalantari S, Sarswat N, Adatya S, Ota T, Jeevanandam V, Mor-Avi V, Lang RM, Uriel N. "Outflow Cannula Systolic Slope in Patients With Left Ventricular Assist Devices: A Novel Marker of Myocardial Contractility." ASAIO Journal (2018)

Grinstein J, Lourenco LM, Te HS, Renz, JF, Jeevanandam V, Uriel, N. "Accepting Hearts from Hepatitis C Positive Donors: Can We Expand the Donor Pool?." Journal of Cardiac Failure (2017)

Tehrani DM, Grinstein J, Kalantari S, Kim G, Sarswat N, Adatya S, Sayer G, Uriel N. "Cardiac Output Assessment in Patients Supported with Left Ventricular Assist Devices: Discordance between Thermodilution and Indirect Fick Cardiac Output Measurements." ASAIO Journal (2017)

Grinstein J, Kruse E, Sayer G, Fedson S, Kim GH, Jorde UP, Juricek C, Ota T, Jeevanandam V, Lang RM, Uriel N. "Accurate Quantification Methods for Aortic Insufficiency Severity in Patients With LVAD: Role of Diastolic Flow Acceleration and Systolic-to-Diastolic Peak Velocity Ratio of the Outflow Cannula." JACC: Cardiovascular Imaging (2016)

Grinstein J, Estrada J, Sayer G, Kim GH, Sarswat N, Adatya S, Nathan S, Paul JD, Blair JEA, Jeevanandam V, Lang R, Uriel N, Shah AP. "Left Ventricular Assist Device Deactivation Via Percutaneous Closure of the Outflow Graft." Journal of Cardiac Failure (2016)

Grinstein J, Kruse E, Sayer G, Fedson S, Kim GH, Sarswat N, Adatya S, Ota T, Jeevanandam V, Mor-Avi V, Lang RM, Uriel N. "Novel Echocardiographic Parameters of Aortic Insufficiency in Continous Flow Left Ventricular Assist Devices and Clinical Outcome." Journal of Heart and Lung Transplantation(2016)

Grinstein J, Kruse E, Collins K, Sayer G, Fedson S, Kim GH, Sarswat N, Adatya S, Ota T, Jeevanandam V, Mor-Avi V, Uriel N, Lang RM. "Screening for Outflow Cannula Malfunction of Left Ventricular Assist Devices Using Doppler Echocardiography: New LVAD Specific Reference Values for Contemporary Devices." Journal of Cardiac Failure (2016)

Grinstein J, Bonaca MP, Jarolim P, Conrad MJ, Bohula-May E, Deenadayalu N, Braunwald E, Giugliano RP, Newby LK, Sabatine MS and Morrow DA. "Prognostic Implications of Low Level Cardiac Troponin Elevation Using High-Sensitivity Cardiac Troponin T." Clinical Cardiology (2015)

ashetto R, Grinstein J, Del Sorbo L, Khine AA, Voglis S, Tullis E, Slutsky AS, Zhang H. "Role of human neutrophil peptides in the initial interaction between lung epithelial cells and CD4+ lymphocytes." Journal of Leukocyte Biology (2007)


Review Articles

Kalathiya RJ, Grinstein J, Uriel N, Shah AP. "Percutaneous Transcatheter Therapies for the Management of Left Ventricular Assist Device Complications." Journal of Invasive Cardiology (2017)

Grinstein J, Nathan S. "Differential hemodynamic profile of high-capacity intraaortic balloon pumps: new promise for an antiquated technology?."Journal of Invasive Cardiology (2015)

Grinstein J, Burkhoff D. "Innovative devices for advanced heart failure: exploring the current state and future direction of device therapies." Current Opinions in Cardiology (2015)

Grinstein J, Gomberg-Maitland M. "Management of pulmonary hypertension and right heart failure in the intensive care unit." Current Hypertension Reports (2015)

Grinstein J, Hofmann Bowman MA, Fedson S. "Ventricular Assist Devices in Advanced Heart Failure: Exploring the Technology’s Current Utilization, Limitations and Future Directions." Journal of Cardiobiology (2014)

Grinstein J, Cannon CP. "Aspirin resistance: current status and role of tailored therapy." Clinical Cardiology (2012)

Internet Publications

Grinstein J, Imamura T, Kruse E, Kalantari S, Rodgers D, Adatya S, Sayer G, Kim GH, Sarswat N, Raihkelkar J, Ota T, Jeevanandam V, Burkhoff D, Lang R, Uriel N. "Echocardiographic Predictors of Hemodynamics in Patients Supported with Left Ventricular Assist Devices." Journal of Cardiac Failure (2018)
Grinstein J, Uriel N, Upadhyay GA, "Management of Cardiac Implantable Electronic Devices (CIEDs) in Patients with Left Ventricular Assist Devices,"American College of Cardiology, 2016, http://www.acc.org/latest-in-cardiology/articles/2016/01/22/14/19/management-of-cieds-in-patients-with-lvads

Abstracts

Grinstein J, Kruse E, Kalantari Tannenbaum S, Rodgers D, Adatya S, Sayer G, Kim GH, Sarswat N, Raikhelkar J, Kagan V, Costantini H, Burkhoff D, Jeevanandam V, Lang R, Uriel N. "Echocardiographic Predictors of Hemodynamics in Patients Supported with Left Ventricular Assist Devices." Journal of Heart and Lung Transplantation (2017)

Grinstein J, Garan AR, Flatley E, Kim GH, Mai X, Sarswat N, Kalantari S, Adatya S, Raikhelkar J, Sayer G, Oesterle A, Jeevanandam V, Moss J, Uriel N. "Increased Rate of Pump Thrombosis and Cardioembolic Events Following Ventricular Tachycardia Ablation in Patients Supported with Left Ventricular Assist Devices." Journal of Heart and Lung Transplantation (2017)

Kim GH, Sayer G, Rodgers D, Woodward R, Arnold P, Sarswat N, Grinstein J, Kalantari S, Adatya S, Yee J, Ota T, Jeevanandam V, Uriel N. "Reduced PF4 and C6orf25 Gene Copies Prior to LVAD in Patients with Thromboembolic Events." Journal of Heart and Lung Transplantation (2017)

Grinstein J, Medvedofsky D, Flatley E, Moss, J, Beiser D, Adatya S, Sayer G, Sarswat N, Raikhelkar J, Kim GH, Kagan V, Lee W, Ota T, Jeevanandam V, Lang R, Uriel N. "Right Ventricular Pacing Improves Functional Status and Quality of Life Compared to Biventricular Pacing in Left Ventricular Assist Device Patie." Journal of Heart and Lung Transplantation��(2017)

Smith BA, Bassi N, Wright C, Kalantari-Tannenbaum S, Grinstein J, Kim G, Sayer G, Adatya S, Sarswat N, Fedson S, Ota T, Jeevanandam V, Uriel N. "The Impact of Race on Hemodynamics and Heart Transplant Outcomes." Journal of Heart and Lung Transplantation (2017)

Tannenbaum SK, Uraizee I, Grinstein J, Smith B, Marinescu K, Sayer G, Sarswat N, Kim GH, Adatya S, Jeevanandam V, Ota T, Husain A, Uriel N. "Discordance Between C4d Staining by Immunohistochemistry and Immunofluorescence and Clinical Outcomes." Journal of Heart and Lung Transplantation (2016)

Tehrani DM, Grinstein J, Anyanwu EC, Kim G, Sarswat N, Adatya S, Sayer G, Uriel N. "Discordance between Thermodilution and Indirect Fick Cardiac Outpit Measurements in LVAD Patients." Journal of Cardiac Failure (2016)

Grinstein J, Rodgers DE, Tannenbaum SK, Adatya S, Sarswat N, Kim GH, Sayer G, Ota T, Jeevanandam V, Mor-Avi V, Burkhoff D, Uriel N. "HVAD Waveform as a Surrogate Marker of Cardiac Index and Pulmonary Capillary Wedge Pressure." Journal of Heart and Lung Transplantation (2016)

Sayer G, Kruse E, Addetia K, Grinstein J, Adatya S, Sarswat N, Kim GH, Ota T, Jeevanandam V, Lang R, Uriel N. "Impact of Aortic Insufficiency on Unloading Properties of Continous-Flow Left Ventricular Assist Devices." Journal of Heart and Lung Transplantation (2016)

Grinstein J, Kruse E, Sayer G, Kim GH, Sarswat N, Adatya S, Ota T, Jeevanandam V, Mor-Avi V, Lang RM, Uriel N. "LVAD Outflow Cannula Systolic Slope in Patients with Left Ventricular Assist Devices: A Marker of Myocardial Contractility." Journal of Heart and Lung Transplantation (2016)

Kalantari S, Grinstein J, Smith B, Sayer G, Adatya S, Sarswat N, Kim G, Burkhoff D, Uriel N. "The Hemodynamic Effects of Intravenous Inotrope/Vasodilator Therapy in the Beta-Blocker Era." Journal of the American College of Cardiology (2016)

Tannenbaum SK, Grinstein J, Smith B, Marinescu K, Sarswat N, Adatya S, Sayer G, Kim GH, Ota T, Jeevanandam V, Uriel N. "The Hemodynamic Effects of Milrinone in the Beta-Blocker Er." Journal of Heart and Lung Transplantation (2016)

Kruse E, Grinstein J, Sayer G, Fedson S, Kim GH, Shah A, Paul J, Uriel N, Lang RM. "Doppler echocardiographic assessment of the left ventricular assist device outflow cannula in the screening of cannula malfunction." Journal of the American Society of Echocardiography (2015)

Grinstein J, Kruse E, Collins KA, Sayer G, Fedson S, Kim GH, Jeevanandam V, Lang RM, Uriel N. "Improved prognostic performance of novel parameters for grading aortic insufficiency severity in patients with left ventricular assist devices." Circulation (2015)

Grinstein J, Kruse E, Collins KA, Sayer G, Fedson S, Kim GH, Jeevanandam V, Lang RM, Uriel N. "Novel parameters for grading aortic insufficiency severity in patients with left ventricular assist devices." Journal of the American Society of Echocardiography (2015)

Grinstein J, Kruse E, Sayer G, Fedson S, Kim GH, Jorde UP, Juricek C, Ota T, Jeevanandam V, Lang RM, Uriel N. "Quantification of Aortic Insufficiency in Patients With Left Ventricular Assist Devices: A Novel Approach Combining Invasive Hemodynamics and Echocardiography." Journal of Heart and Lung Transplantation (2015)

Grinstein J, Kruse E, Sayer G, Fedson S, Kim GH, Shah A, Paul J, Lang RM, Uriel N. "Screening for Outflow Cannula Malfunction of Left Ventricular Assist Devices Using Doppler Echocardiography: Establishing New Reference Values." Circulation (2015)

Grinstein J, Bonaca M, Sabatine M, Jarolim P, Conrad M, Braunwald E, Giugliano R, Newby LK, Morrow D. "Prognostic implications of low-level cardiac troponin elevation using the high-sensitivity assay for cardiac troponin T: Results from EARLY ACS & SEPIA-TIMI 42." Journal of the American College of Cardiology (2013)

 
Insurance


Practice Locations
  • 110 Irving Street Northwest
    Advanced Heart Failure Center Ste 1F-1202
    Washington, DC 20010
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    Phone: 202-877-4698

Member of Medical Staff
Awards
  • MedStar New Investigator Grant - MedStar Health Research Institute
  • Morton Arnsdorf Award for Best Research - University of Chicago
  • Dean’s Scholarship for Outstanding Promise in Medicine - University of Chicago
  • American Society for Clinical Pathology Award for Academic Excellence and Achievement
  • Dr. Kathleen Terroux Prize in Physiology - McGill University