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Specialties
- Pediatric Hematology
- Pediatric Medical Oncology
Conditions I Treat
- abdominal pain
- acute lymphocytic leukemia
- acute myelogenous leukemia
- adamantinoma
- adverse effects to anticoagulants Show All
Procedures I Perform
- adjuvant chemotherapy
- biological targeted therapy
- breast cancer immunotherapy
- cancer chemotherapy
- cancer immunotherapy Show All
About the Provider
Jeffrey A. Toretsky, MD, serves as chief of MedStar Georgetown University Hospital’s Division of Pediatric, Adolescent, and Young Adult Hematology/Oncology. Dr. Toretsky is an internationally recognized expert in sarcomas in children, adolescents, and young adults. He is the principal investigator and director of the NIH-funded Molecular Oncology Program at MedStar Georgetown University Hospital’s Lombardi Comprehensive Cancer Center and co-leads a regional multidisciplinary sarcoma clinic.
Dr. Toretsky and a multidisciplinary team are engaged with all aspects of pediatric hematology/oncology from diagnosis through survivorship. His laboratory is pursuing new and targeted therapies for Ewing sarcoma, including a new medication for Ewing sarcoma currently in phase 1 clinical trials.
Dr. Toretsky’s areas of clinical expertise include:
- Sarcoma
- Diagnosis and treatment of rare tumors
- Benign and malignant hematology
- Brain tumors
- Other childhood, adolescent and young adult tumors
Learn more about Toretsky Lab here.
Education
- Fellowship Program: National Institutes of Health Clinical Center (1998)
- Fellowship Program: National Institute of Health (1998)
- Fellowship Program: National Cancer Institute (1997)
- Fellowship Program: Medical College of Virginia-VCU (1991)
- Residency Program: Medical College of Virginia-VCU (1991)
- Residency Program: Marymount College of Virginia (1991)
- Residency Program: Medical College of Virginia Hospitals (1991)
- Residency Program: Duke University Medical Center (1989)
- Internship Program: Duke University Medical Center (1989)
- Internship Program: Duke University Hospital (1989)
- Medical School: University of Minnesota Medical School (1988)
- Medical School: University of Minnesota School of Medicine (1988)
- Board Certification: American Board of Pediatrics, Pediatric Hematology-Oncology
Publications
- Anderson ND, de Borja R, Young MD, Fuligni F, Rosic A, Roberts ND, Hajjar S, Layeghifard M, Novokmet A, Kowalski PE, Anaka M, Davidson S, Zarrei M, Id Said B, Schreiner LC, Marchand R, Sitter J, Gokgoz N, Brunga L, Graham GT, Fullam A, Pillay N, Toretsky JA, Yoshida A, Shibata T, Metzler M, Somers GR, Scherer SW, Flanagan AM, Campbell PJ, Schiffman JD, Shago M, Alexandrov LB, Wunder JS, Andrulis IL, Malkin D, Behjati S, Shlien A. Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors. Science. 2018 Aug 31;361(6405). PubMed PMID: 30166462. Pubmed Central PMCID: 6176908.
- Gorthi A, Romero JC, Loranc E, Cao L, Lawrence LA, Goodale E, Iniguez AB, Bernard X, Masamsetti VP, Roston S, Lawlor ER, Toretsky JA, Stegmaier K, Lessnick SL, Chen Y, Bishop AJR. Author Correction: EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma. Nature. 2018 Jul;559(7715):E11. PubMed PMID: 29950716.
- Smith-Guzman NE, Toretsky JA, Tsai J, Cooke RG. A probable primary malignant bone tumor in a pre-Columbian human humerus from Cerro Brujo, Bocas del Toro, Panama. International journal of paleopathology. 2018 Jun;21:138-46. PubMed PMID: 29778411.
- Selvanathan SP, Graham GT, Grego AR, Baker TM, Hogg JR, Simpson M, Batish M, Crompton B, Stegmaier K, Tomazou EM, Kovar H, Uren A, Toretsky JA. EWS-FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex. Nucleic acids research. 2019 Oct 10;47(18):9619-36. PubMed PMID: 31392992. Pubmed Central PMCID: 6765149.
- Spriano F, Chung EYL, Gaudio E, Tarantelli C, Cascione L, Napoli S, Jessen K, Carrassa L, Priebe V, Sartori G, Graham G, Selvanathan SP, Cavalli A, Rinaldi A, Kwee I, Testoni M, Genini D, Ye BH, Zucca E, Stathis A, Lannutti B, Toretsky JA, Bertoni F. The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Aug 15;25(16):5167-76. PubMed PMID: 31182435.
- Ko, K., Kitani, T., Harris, B. T., Anaizi, A. N., Solomon, D., Perry, A., Toretsky, J. and Ozdemirli, M. A novel PARD3B-NUTM1 fusion in an aggressive primary CNS embryonal tumor in a young adult. Acta Neuropathol Commun. 2020 Jul 17;8(1):112. doi: 10.1186/s40478-020-00991-w.
- Pecora, A., Halpern, S., Weber, M., Paleoudis, E. G., Panush, D., Patterson, F. and Toretsky, J. Rapid and Complete Response to Combination Anti-CTLA-4 and Anti-PD-1 Checkpoint Inhibitor Therapy in a Patient With Stage IV Refractory End-stage Epithelioid Sarcoma: A Case Report. J Immunother. 2020 Nov/Dec;43(9):286-290. doi: 10.1097/CJI.0000000000000332.
- J. Dong, R. Y. Zhang, N. Sun, J. Hu, M. D. Smalley, A. Zhou, Y. Hua, W. Rothermich, M. Chen, J. Chen, J. Ye, P.-C. Teng, D. Qi, J. A. Toretsky, J. S. Tomlinson, M. Li, P. S. Weiss, S. J. Jonas, N. Federman, L. Wu, M. Zhao,* H.-R. Tseng,* Y. Zhu. Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma‐Derived Extracellular Vesicles for Downstream Functional Studies. Advanced Functional Materials. 2020 September 13; https://doi.org/10.1002/adfm.202003237.
For complete list: https://www.ncbi.nlm.nih.gov/pubmed/?term=Toretsky+J
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Practice Locations
Member of Medical Staff
- MedStar Georgetown University Hospital
Awards
- Fellow, National Academy of Inventors, 2018
- Outstanding Faculty Entrepreneur in Medical Science, Georgetown Business School, 2012
- Georgetown University Medical Center Convocation Honoree for Outstanding Research, 2009
- National Academies Keck Futures Initiatives Conference, 2009
- Georgetown University Medical Center Convocation Honoree, 2008
- Burroughs Wellcome Clinical Scientist Award in Translational Research, 2008
