Claudine Janet Diana Isaacs, MD| Medical Oncology, Cancer Genetics | MedStar Health
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Claudine Janet Diana Isaacs

Claudine Janet Diana Isaacs, MD
Provider is directly employed by MedStar Health

4.9 out of 5 (532 reviews)

Specialties: Medical Oncology, Cancer Genetics, Breast Medical Oncology

Languages: English, French

202-444-9429

About me

Dr. Claudine Isaacs is a medical oncologist who specializes in the care of women with all stages of breast cancer. She is Professor of Medicine and Oncology, Associate Director of Clinical Research and Leader of the Clinical Breast Cancer Program at the Georgetown Lombardi Comprehensive Cancer Center. She is also the Medical Director of the Jess and Mildred Fisher Center for Hereditary Cancer and Clinical Genomics Research. She has been practicing for over 20 years.

Dr. Isaacs received her medical degree and internal medicine residency training at McGill University, Canada. She completed fellowship training in the Division of Hematology and Oncology at McGill University and a Fellowship in Breast Medical Oncology in the Division of Medical Oncology at Georgetown University. She then joined the faculty in the Department of Medicine and Oncology at Georgetown University.

Dr. Isaacs has extensive experience in the conduct of clinical trials focusing on all aspects of breast cancer. Additional research interests include cancer risk assessment and medical management and prevention strategies for women at high risk for breast cancer. She has served as the principal investigator of a variety of clinical trials in the treatment of early-stage and metastatic breast cancer, and currently serves as the principal investigator of the Translational Breast Cancer Research Consortium (TBCRC), the ISPY2 trial at Georgetown University. She has authored over 200 peer-reviewed publications. She has also served on a number of committees, including the Cancer Education Committee at the American Society of Clinical Oncology (ASCO), the ASCO Scientific Program Committee, the Breast Oncology Local Diseases Task Force of the Breast Steering Committee of the National Cancer Institute, and most recently the ASCO guidelines committee. She has been named one of America's Top Cancer Doctors by Castle Connolly/Newsweek for many years running, and has also received designations from Washingtonian Magazine and Women's Health Magazine.


Dr. Isaacs' Philosophy of Care:

I strive to personalize the care of my patients by tailoring state-of-the-art therapy to their individual situations and by providing them with access to cutting-edge clinical trials. Equally important is that the care of my patients extends well beyond focusing just on the optimal therapy of their cancer.  My approach to care is to relate to each of my patients as individuals in the context of their lives, and not solely based on the characteristics of their disease. To that end, I work with a wonderful and dedicated multidisciplinary group of expert colleagues who are deeply committed to and involved with our patients' care. The whole team is focused solely on breast cancer and includes medical oncologists, surgeons, radiation oncologists, breast imagers, and pathologists who are supported by an experienced team of clinical nurse coordinators, nurse navigators, research nurses, genetic counselors and social workers, all championing a multidisciplinary approach to breast cancer diagnosis, treatment and recovery. We are not treating a disease. We are treating a person and we are here to provide state-of-the-art medical treatment and to accompany that person navigates their cancer journey.

Clinical areas of focus

  • Cancer Genetics Consultation
  • Family History-Based Cancer Risk Assessment
  • Genetic Testing For Cancer Patients
  • Genetic Testing For Hereditary Cancer
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Procedures I perform

  • A1c Testing
  • Abdominal Wall Biopsy
  • Adjuvant Hormone Therapy
  • Antiangiogenic Therapy
  • Bladder Tumor Prevention
  • Bone Biopsy
  • Brca Gene Testing
  • Breast Biopsy
  • Breast Cancer
  • Breast Cancer And Fertility
  • Breast Cancer Chemoprevention
  • Breast Cancer Pain Management
  • Breast Cancer Screening
  • Breast Cancer Treatment
  • Breast Density Evaluation
  • Breast Infection Treatment
  • Breast Lift Surgery
  • Breast Seroma Aspiration
  • Ca 19-9 Test
  • Cancer Genetics Consultation
  • Cancer Risk Assessment
  • Cea Testing For Colorectal Cancer
  • Chemotherapy Administration
  • Circulating Tumor Cell Monitoring
  • Diagnostic Breast Imaging
  • Diagnostic Mammography
  • Digital Breast Tomosynthesis
  • Ductal Carcinoma In Situ (DCIS) Surgery
  • Family History-Based Cancer Risk Assessment
  • Fine Needle Aspiration Biopsy
  • Fish Testing For Breast Cancer
  • Genetic Counseling
  • Genetic Testing For Cancer Patients
  • Genetic Testing For Down Syndrome
  • Genetic Testing For Hereditary Cancer
  • Genetic Testing For Stargardt Disease
  • Genomic Testing For Cancer
  • High-Risk Breast Lesion Management
  • Hormone Replacement Therapy
  • Immunotherapy
  • Introduction Of Antineoplastic
  • Liquid Biopsy
  • Liver Biopsy
  • Lymph Node Biopsy
  • Lynch Syndrome Testing
  • Mammaprint Testing
  • Modified Radical Mastectomy
  • Pathology Consultation
  • Preventive Medicine Counseling
  • Prophylactic Oophorectomy
  • Psa Testing
  • Risk-Reducing Mastectomy
  • Risk-Reducing Salpingo-Oophorectomy
  • Selective Estrogen Receptor Modulator (SERM) Therapy
  • Targeted Genome Sequencing
  • Tumor Immunohistochemistry
  • Tumor Marker Testing
  • Ultrasound
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Practice locations

Distance from Change LocationEnter your Location

3800 Reservoir Rd NW
Lombardi Cancer Center
Washington, DC, 20007

202-444-2223

Fax 202-444-1229

Get Directions

miles away

Fax 202-444-1229

Insurance

MedStar Health accepts most major health insurance plans. If you are uncertain as to whether your individual health insurance plan is accepted at MedStar Health, please call your insurance company.

  • List of insurance plans we accept
    • Amerigroup DC Healthy Families
    • Healthy Blue (HMO, POS)
    • HumanaChoice PPO
    • Aetna Student Health Insurance
    • Kaiser Permanente Signature - Added Choice
    • Medicare Direct
    • Alterwood Advanatge HMO & DSNP Plans
    • MD IPA (HMO) & MD IPA Preferred Cardiac Global
    • Aetna Open Choice (PPO)
    • Aetna Better Health of MD
    • Cigna True Choice Plus Medicare (PPO)
    • CareFirst MedStar Select PPO
    • Johns Hopkins Advantage MD PPO
    • Sentara Health
    • Maryland Physicians Care MCO
    • M.D. IPA (HMO)
    • MedStar Family Choice DC Healthcare Alliance
    • Anthem BCBS Medi Blue Dual Adv
    • CareFirst MedStar PPO
    • Anthem BCBS of VA HealthKeepers Plus
    • BlueChoice Open Access
    • TriWest Healthcare Alliance
    • Network OA
    • First Health PPO
    • CareFirst NASCO
    • Tricare Reserve Select
    • Kaiser Permanente Medicare Plus
    • OCI Direct (HMO)
    • IH-Open EPO Plus
    • United Healthcare Select HMO - EPO/NPP
    • Aetna Basic
    • CareFirst BlueChoice HMO
    • Humana Gold Plus HMO
    • IH-Open HMO
    • Private Health Care Systems (PPO)
    • BCBS Out-of-State Medicare Plans (Blue Advantage)
    • Amerigroup DC Alliance
    • IH-POS
    • First Health PPO
    • Kaiser Permanente HMO Plus and DHMO Plus Member
    • Erickson Advantage Plans
    • Cigna Alliance Medicare (HMO)
    • United Medicare Private Fee-for-Service (PFFS) plans
    • Select HMO/HealthFund/Health Network
    • Anthem Federal Employee Program Standard
    • CIGNA Indemnity
    • NYC Medicare Advantage Plus
    • Aetna HMO-Open Access/Select OA/HealthFund/Health Network Option OA
    • Choice POS II Open Access
    • CIGNA PPO
    • Anthem Federal Employee Program Basic
    • Choice Care Network/HUMANA (PPO)
    • Fee-for-Service (FFS) District of Columbia, Maryland and Virginia Medicaid
    • IH-EPO Plus
    • CareFirst Blue Choice Opt Out Open Access
    • IH-PPO
    • HealthyBlue PPO
    • Anthem BCBS of VA Key Care POS/PPO/Indemnity
    • UnitedHealthcare and AARP Medicare Complete Plans
    • CareFirst Dual Prime HMO-SNP
    • Cigna Preferred Medicare (HMO)
    • Kaiser Permanente Flexible Choice 3-tier POS
    • AmeriHealth Caritas DC Healthy Families
    • Kaiser Permanente Select - Added Choice
    • HumanaChoice Honor's plan PPO
    • UnitedHealthcare Medicare Advantage DSNP District of Columbia
    • HUMANA/Choice Care Medicare Plans (Choice, Gold Choice)
    • MultiPlan, Inc
    • Kaiser Permanente Select Cardiac Global
    • DC/MD SHOP QHP Small Business Plans
    • IH-POS Plus
    • TRICARE East Select
    • Anthem BCBS of VA HealthKeepers (HMO)
    • Veterans Affairs Community Care Network
    • Cigna TotalCare (HMO D-SNP)
    • Choice POS II
    • CareFirst Maryland Point of Service Plan
    • Cigna True Choice Medicare (PPO)
    • Jai Medical Systems - Maryland Health Choice
    • UnitedHealthcare Medicare Adv. Special Needs Plans
    • United Healthcare Choice
    • Geisinger Medicare Advantage
    • Medicare FFS
    • Aetna Quality Point of Service (POS)
    • MedStar Family Choice DC Healthy Families
    • CIGNA HMO & Network (HMO)
    • IH-Indemnity
    • CIGNA POS/Network POS
    • Cigna Achieve Medicare (HMO C-SNP)
    • Kaiser Permanente Medicare Advantage Signature and Select
    • CareFirst Community Health Plan of MD
    • Aetna Managed Choice Open Access (POS)
    • CIGNA HMO Open Access
    • Coventry Health Care of Virginia
    • United Healthcare Community Plan - VA Medicaid MCO
    • United Healthcare Choice Plus Cardiac Global
    • Choice POS
    • Aetna Advantage 5750
    • Aetna Advantage 6350
    • Aetna Classic 5000PD
    • Aetna Worker's Compensation Network
    • UHC Group Medicare Advantage Plans (HMO, POS, PPO)
    • CareFirst BlueCross BlueShield Advantage Core/Enhanced
    • United Healthcare Choice Cardiac Global
    • OA Plus
    • Navigate
    • Aetna VA Exchange
    • Aetna Signature Administrator PPO/TPA
    • Humana Medicare Advantage - PPO
    • United Healthcare Choice Plus
    • TRICARE for Life East
    • Police and Fire Clinic
    • CareFirst Blue Preferred PPO
    • Anthem BCBS of VA HealthKeepers (POS & POS OA)
    • Optimum Choice Preferred (POS)
    • AmeriHealth Caritas DC Healthcare Alliance
    • Optimum Choice & Optimum Choice Preferred (POS) Cardiac Global
    • Aetna Elect Choice/ EPO (Aetna Health Fund)
    • Choice Fund PPO
    • Kaiser Permaenete Signature - Added Choice Cardiac Global
    • Coventry Health Care National Network PPO
    • Health Services for Children with Special Needs
    • Private Fee-for-Service Plans (PFFS)
    • CareFirst Maryland Indemnity or PPO
    • Kaiser Maryland Medicaid MCO
    • Blue Choice Advantage
    • CareFirst Blue Choice Opt Out Plus Open Access (POS)
    • IH-Network Only Plus
    • M.D. IPA Preferred (POS)
    • UHC Passport
    • Kaiser Permanente Flexible Choice POS Cardiac Global
    • IH-Open Network Only Plus
    • Anthem BCBS Medi Blue SNP
    • CareFirst Group Medicare Advantage prescription drug benefit (PPO)
    • Mamsi Life & Health (Indem./PPO) Cardiac Global
    • Aetna Advantage 6350PD
    • Medicare Advantage - Advantra Value (PPO)
    • Aetna Better Health of VA
    • IH-Open POS II
    • United Healthcare Select Plus (POS)
    • AMERIVANTAGE/Amerigroup Community Care
    • Anthem BCBS Medi Blue Plus
    • Great-West Healthcare POS/CIGNA
    • HighMark
    • Johns Hopkins Advantage MD HMO
    • Lasso Healthcare - Medicare Medical Savings Account
    • POS OA
    • Aetna Managed Choice (POS)
    • Coventry of Delaware HMO/PPO
    • Employee Health Plan
    • United HealthCare Community Plan - Maryland Health Choice Program
    • Aetna Premier 200PD
    • Mamsi Life & Health (Indem./PPO)
    • CareFirst Federal Employee Program (Std. & Basic PPO)
    • CareFirst Administrators
    • TRICARE East Prime
    • Priority Partners - Maryland Health Choice
    • Options PPO Cardiac Global
    • CIGNA EPO
    • IH-Open HMO Option
    • Aetna Elect Choice/ Open Access (POS)
    • CIGNA PPO Plus
    • CareFirst Blue Card Program
    • Advantra Platinum (PPO)
    • Core Essential (HMO)
    • Aetna Medicare Advantage HMO & PPO Plans
    • IH-Open POS Plus
    • Optimum Choice
    • United Student Resources
    • IH-HMO
    • Kaiser Permanente Select
    • United Healthcare Navigate Cardiac Global
    • Aetna HMO
    • Beech Street PPO
    • Johns Hopkins Advantage MD PLUS PPO
    • MedStar Family Choice - Maryland Health Choice
    • UnitedHealthcare Individual Exchange Plans
    • Aetna Classic 5000
    • BCBS of Michigan (BCN Advantage,Security Blue, Freedom, Medicare PLUS Blue Group PPO)
    • CIGNA Connect EPO
    • Magellan Complete Care of VA - VA Medicaid MCO
    • Aetna Traditional Choice (PPO)
    • CareFirst EPO
    • Kaiser Permanente Signature
    • CareFirst (NCA) Indemnity
    • Humana Medicare Advantage - HMO Open Access
    • Uniformed Services Family Health Plan
    • WellPoint Maryland - Maryland Health Choice
    • Aetna Medicare Advantage PFFS Plan
    • CareFirst FEP Blue Focus
    • CareFirst Group Medicare Advantage
    • CIGNA SureFit (HMO)
    • Optima Family Care MCO - VA Medicaid MCO
    • Aetna Classic 3500
    • United Healthcare Options (PPO)
    • United Healthcare Select HMO-EPO/NPP Cardiac Global

Videos

Education

Board Certification: American Board of Internal Medicine, Medical Oncology/Medical Oncology

Fellowship: Georgetown University School of Medicine GME (1993)

Fellowship: McGill University (1992)

Residency: McGill University Faculty of Medicine (1990)

Internship: Montreal General Hospital (1988)

Medical School: McGill University (1987)

Awards

  • Washingtonian Top Doc 2025 America’s Top Doctors for Women, Women’s Health Magazine
  • Marquis Who’s Who in America            
  • America’s Top Doctors, Castle Connolly
  • Newsweek’s Top Cancer Doctors
  • Top Doctors Washington DC, Washingtonian Magazine
  • Global Directory Top Doctors
  • Global Directory of Who’s Who
  • Top Doctors Washington DC Area, Northern Virginia Magazine
  • Estelle Ramey Mentorship Award, Georgetown University School of Medicine

Ratings and reviews

  • Explanations the care provider gave you about your problem or condition

    4.9
  • Extent to which the care provider listened to you

    4.9
  • Care provider’s discussion of any proposed treatment (options, risks, benefits, etc.)

    4.9
  • Provider included you in decisions

    4.9
  • Concern the care provider showed for your questions or worries

    4.9
  • Likelihood of recommending this care provider to others

    4.9
  • Apr 18, 2026

    Dr Isaacs is a compassionate, thoughtful and supportive professional practitioner who uses her expertise with confident ease

  • Jan 15, 2026

    Dr Issacs is excellent

  • Dec 18, 2025

    Dr Claudine Isaacs is outstanding