Claudine Janet Diana Isaacs, MD| Cancer Genetics, Medical Oncology | MedStar Health
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Claudine Janet Diana Isaacs

Claudine Janet Diana Isaacs, MD
Provider is directly employed by MedStar Health

4.9 out of 5 (532 reviews)

Specialties: Cancer Genetics, Medical Oncology, Breast Medical Oncology

Languages: English, French

202-444-9429

About me

Dr. Claudine Isaacs is a medical oncologist who specializes in the care of women with all stages of breast cancer. She is Professor of Medicine and Oncology, Associate Director of Clinical Research and Leader of the Clinical Breast Cancer Program at the Georgetown Lombardi Comprehensive Cancer Center. She is also the Medical Director of the Jess and Mildred Fisher Center for Hereditary Cancer and Clinical Genomics Research. She has been practicing for over 20 years.

Dr. Isaacs received her medical degree and internal medicine residency training at McGill University, Canada. She completed fellowship training in the Division of Hematology and Oncology at McGill University and a Fellowship in Breast Medical Oncology in the Division of Medical Oncology at Georgetown University. She then joined the faculty in the Department of Medicine and Oncology at Georgetown University.

Dr. Isaacs has extensive experience in the conduct of clinical trials focusing on all aspects of breast cancer. Additional research interests include cancer risk assessment and medical management and prevention strategies for women at high risk for breast cancer. She has served as the principal investigator of a variety of clinical trials in the treatment of early-stage and metastatic breast cancer, and currently serves as the principal investigator of the Translational Breast Cancer Research Consortium (TBCRC), the ISPY2 trial at Georgetown University. She has authored over 200 peer-reviewed publications. She has also served on a number of committees, including the Cancer Education Committee at the American Society of Clinical Oncology (ASCO), the ASCO Scientific Program Committee, the Breast Oncology Local Diseases Task Force of the Breast Steering Committee of the National Cancer Institute, and most recently the ASCO guidelines committee. She has been named one of America's Top Cancer Doctors by Castle Connolly/Newsweek for many years running, and has also received designations from Washingtonian Magazine and Women's Health Magazine.


Dr. Isaacs' Philosophy of Care:

I strive to personalize the care of my patients by tailoring state-of-the-art therapy to their individual situations and by providing them with access to cutting-edge clinical trials. Equally important is that the care of my patients extends well beyond focusing just on the optimal therapy of their cancer.  My approach to care is to relate to each of my patients as individuals in the context of their lives, and not solely based on the characteristics of their disease. To that end, I work with a wonderful and dedicated multidisciplinary group of expert colleagues who are deeply committed to and involved with our patients' care. The whole team is focused solely on breast cancer and includes medical oncologists, surgeons, radiation oncologists, breast imagers, and pathologists who are supported by an experienced team of clinical nurse coordinators, nurse navigators, research nurses, genetic counselors and social workers, all championing a multidisciplinary approach to breast cancer diagnosis, treatment and recovery. We are not treating a disease. We are treating a person and we are here to provide state-of-the-art medical treatment and to accompany that person navigates their cancer journey.

Clinical areas of focus

  • Cancer Genetics Consultation
  • Family History-Based Cancer Risk Assessment
  • Genetic Testing For Cancer Patients
  • Genetic Testing For Hereditary Cancer
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Procedures I perform

  • A1c Testing
  • Abdominal Wall Biopsy
  • Adjuvant Hormone Therapy
  • Antiangiogenic Therapy
  • Bladder Tumor Prevention
  • Bone Biopsy
  • Brca Gene Testing
  • Breast Biopsy
  • Breast Cancer
  • Breast Cancer And Fertility
  • Breast Cancer Chemoprevention
  • Breast Cancer Pain Management
  • Breast Cancer Screening
  • Breast Cancer Treatment
  • Breast Density Evaluation
  • Breast Infection Treatment
  • Breast Lift Surgery
  • Breast Seroma Aspiration
  • Ca 19-9 Test
  • Cancer Genetics Consultation
  • Cancer Risk Assessment
  • Cea Testing For Colorectal Cancer
  • Chemotherapy Administration
  • Circulating Tumor Cell Monitoring
  • Diagnostic Breast Imaging
  • Diagnostic Mammography
  • Ductal Carcinoma In Situ (DCIS) Surgery
  • Family History-Based Cancer Risk Assessment
  • Fine Needle Aspiration Biopsy
  • Fish Testing For Breast Cancer
  • Genetic Counseling
  • Genetic Testing For Cancer Patients
  • Genetic Testing For Down Syndrome
  • Genetic Testing For Hereditary Cancer
  • Genetic Testing For Stargardt Disease
  • Genomic Testing For Cancer
  • High-Risk Breast Lesion Management
  • Hormone Replacement Therapy
  • Immunotherapy
  • Introduction Of Antineoplastic
  • Liver Biopsy
  • Lymph Node Biopsy
  • Lynch Syndrome Testing
  • Mammaprint Testing
  • Modified Radical Mastectomy
  • Pathology Consultation
  • Preventive Medicine Counseling
  • Prophylactic Oophorectomy
  • Risk-Reducing Mastectomy
  • Risk-Reducing Salpingo-Oophorectomy
  • Selective Estrogen Receptor Modulator (SERM) Therapy
  • Targeted Genome Sequencing
  • Tumor Immunohistochemistry
  • Tumor Marker Testing
  • Ultrasound
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Practice locations

Distance from Change Location Enter your Location

3800 Reservoir Rd NW
Lombardi Cancer Center
Washington, DC, 20007

202-444-2223
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miles away

Fax 202-444-1229

Insurance

MedStar Health accepts most major health insurance plans. If you are uncertain as to whether your individual health insurance plan is accepted at MedStar Health, please call your insurance company.

  • List of insurance plans we accept
    • IH-POS
    • United Healthcare Select Plus (POS)
    • CIGNA Connect EPO
    • Great-West Healthcare POS/CIGNA
    • TRICARE East Select
    • Choice Care Network/HUMANA (PPO)
    • Health Services for Children with Special Needs
    • Aetna Better Health of VA
    • CareFirst Maryland Point of Service Plan
    • Core Essential (HMO)
    • Healthy Blue (HMO, POS)
    • Choice Fund PPO
    • OCI Direct (HMO)
    • Erickson Advantage Plans
    • Anthem BCBS of VA HealthKeepers (HMO)
    • CareFirst Administrators
    • CareFirst Blue Choice Opt Out Plus Open Access (POS)
    • First Health PPO
    • Jai Medical Systems - Maryland Health Choice
    • WellPoint Maryland - Maryland Health Choice
    • AMERIVANTAGE/Amerigroup Community Care
    • Johns Hopkins Advantage MD PLUS PPO
    • Coventry Health Care of Virginia
    • AmeriHealth Caritas DC Healthy Families
    • HealthyBlue PPO
    • Aetna Advantage 6350
    • Aetna Classic 3500
    • BlueChoice Open Access
    • CareFirst BlueCross BlueShield Advantage Core/Enhanced
    • Cigna Preferred Medicare (HMO)
    • Kaiser Permaenete Signature - Added Choice Cardiac Global
    • IH-EPO Plus
    • Aetna Managed Choice Open Access (POS)
    • MedStar Family Choice DC Healthcare Alliance
    • Johns Hopkins Advantage MD PPO
    • CareFirst Group Medicare Advantage prescription drug benefit (PPO)
    • Navigate
    • Anthem Federal Employee Program Standard
    • Network OA
    • HighMark
    • Tricare Reserve Select
    • Anthem BCBS Medi Blue Dual Adv
    • Employee Health Plan
    • HumanaChoice PPO
    • Kaiser Permanente Select - Added Choice
    • UHC Passport
    • UnitedHealthcare Medicare Advantage DSNP District of Columbia
    • Aetna Classic 5000PD
    • Sentara Health
    • Anthem BCBS of VA HealthKeepers Plus
    • IH-PPO
    • United Healthcare Community Plan - VA Medicaid MCO
    • Aetna Premier 200PD
    • CareFirst Dual Prime HMO-SNP
    • IH-Open EPO Plus
    • Blue Choice Advantage
    • CareFirst Blue Card Program
    • MedStar Family Choice DC Healthy Families
    • Geisinger Medicare Advantage
    • Kaiser Permanente HMO Plus and DHMO Plus Member
    • Fee-for-Service (FFS) District of Columbia, Maryland and Virginia Medicaid
    • Aetna Traditional Choice (PPO)
    • Anthem BCBS Medi Blue Plus
    • Aetna Elect Choice/ EPO (Aetna Health Fund)
    • Anthem BCBS of VA Key Care POS/PPO/Indemnity
    • CIGNA HMO & Network (HMO)
    • Anthem Federal Employee Program Basic
    • IH-Network Only Plus
    • United Healthcare Select HMO - EPO/NPP
    • Aetna VA Exchange
    • Aetna Quality Point of Service (POS)
    • M.D. IPA Preferred (POS)
    • Options PPO Cardiac Global
    • TRICARE East Prime
    • Optimum Choice
    • Kaiser Permanente Flexible Choice POS Cardiac Global
    • Mamsi Life & Health (Indem./PPO) Cardiac Global
    • UnitedHealthcare Individual Exchange Plans
    • Optimum Choice Preferred (POS)
    • Magellan Complete Care of VA - VA Medicaid MCO
    • Aetna Advantage 5750
    • CIGNA SureFit (HMO)
    • United Healthcare Choice
    • IH-Open POS Plus
    • Amerigroup DC Alliance
    • Cigna True Choice Medicare (PPO)
    • United Student Resources
    • IH-Open Network Only Plus
    • Anthem BCBS of VA HealthKeepers (POS & POS OA)
    • CareFirst Maryland Indemnity or PPO
    • Humana Medicare Advantage - HMO Open Access
    • Medicare FFS
    • Aetna Student Health Insurance
    • CIGNA PPO
    • Medicare Direct
    • IH-Indemnity
    • IH-Open HMO Option
    • United Healthcare Choice Plus
    • CareFirst BlueChoice HMO
    • Aetna Managed Choice (POS)
    • CareFirst Blue Choice Opt Out Open Access
    • CIGNA PPO Plus
    • Cigna TotalCare (HMO D-SNP)
    • CareFirst Group Medicare Advantage
    • UHC Group Medicare Advantage Plans (HMO, POS, PPO)
    • Cigna Alliance Medicare (HMO)
    • Lasso Healthcare - Medicare Medical Savings Account
    • Choice POS II
    • Choice POS II Open Access
    • HumanaChoice Honor's plan PPO
    • BCBS of Michigan (BCN Advantage,Security Blue, Freedom, Medicare PLUS Blue Group PPO)
    • Aetna Signature Administrator PPO/TPA
    • Aetna HMO
    • AmeriHealth Caritas DC Healthcare Alliance
    • OA Plus
    • Anthem BCBS Medi Blue SNP
    • Beech Street PPO
    • CIGNA POS/Network POS
    • Kaiser Permanente Medicare Advantage Signature and Select
    • IH-HMO
    • Cigna Achieve Medicare (HMO C-SNP)
    • M.D. IPA (HMO)
    • Veterans Affairs Community Care Network
    • UnitedHealthcare and AARP Medicare Complete Plans
    • Coventry of Delaware HMO/PPO
    • TRICARE for Life East
    • Aetna Advantage 6350PD
    • United Healthcare Choice Plus Cardiac Global
    • Amerigroup DC Healthy Families
    • Humana Gold Plus HMO
    • Alterwood Advanatge HMO & DSNP Plans
    • Aetna Basic
    • CIGNA EPO
    • HUMANA/Choice Care Medicare Plans (Choice, Gold Choice)
    • First Health PPO
    • Kaiser Permanente Flexible Choice 3-tier POS
    • MedStar Family Choice - Maryland Health Choice
    • Mamsi Life & Health (Indem./PPO)
    • BCBS Out-of-State Medicare Plans (Blue Advantage)
    • Coventry Health Care National Network PPO
    • UnitedHealthcare Medicare Adv. Special Needs Plans
    • Aetna HMO-Open Access/Select OA/HealthFund/Health Network Option OA
    • DC/MD SHOP QHP Small Business Plans
    • IH-POS Plus
    • United Medicare Private Fee-for-Service (PFFS) plans
    • NYC Medicare Advantage Plus
    • Cigna True Choice Plus Medicare (PPO)
    • IH-Open HMO
    • Medicare Advantage - Advantra Value (PPO)
    • Kaiser Permanente Select
    • Private Fee-for-Service Plans (PFFS)
    • Kaiser Permanente Signature
    • Aetna Medicare Advantage HMO & PPO Plans
    • POS OA
    • IH-Open POS II
    • CareFirst Blue Preferred PPO
    • Maryland Physicians Care MCO
    • Choice POS
    • CareFirst (NCA) Indemnity
    • Uniformed Services Family Health Plan
    • Johns Hopkins Advantage MD HMO
    • Police and Fire Clinic
    • United Healthcare Choice Cardiac Global
    • Aetna Open Choice (PPO)
    • Aetna Elect Choice/ Open Access (POS)
    • MultiPlan, Inc
    • United HealthCare Community Plan - Maryland Health Choice Program
    • Select HMO/HealthFund/Health Network
    • CareFirst FEP Blue Focus
    • Optima Family Care MCO - VA Medicaid MCO
    • CareFirst EPO
    • TriWest Healthcare Alliance
    • Aetna Classic 5000
    • CareFirst MedStar Select PPO
    • CareFirst NASCO
    • Priority Partners - Maryland Health Choice
    • Aetna Medicare Advantage PFFS Plan
    • CIGNA Indemnity
    • United Healthcare Options (PPO)
    • United Healthcare Select HMO-EPO/NPP Cardiac Global
    • Kaiser Permanente Signature - Added Choice
    • Kaiser Maryland Medicaid MCO
    • Optimum Choice & Optimum Choice Preferred (POS) Cardiac Global
    • Private Health Care Systems (PPO)
    • Kaiser Permanente Medicare Plus
    • Advantra Platinum (PPO)
    • CareFirst Federal Employee Program (Std. & Basic PPO)
    • Humana Medicare Advantage - PPO
    • CareFirst MedStar PPO
    • Aetna Better Health of MD
    • Kaiser Permanente Select Cardiac Global
    • Aetna Worker's Compensation Network
    • United Healthcare Navigate Cardiac Global
    • CareFirst Community Health Plan of MD
    • CIGNA HMO Open Access
    • MD IPA (HMO) & MD IPA Preferred Cardiac Global

Videos

Education

Board Certification: American Board of Internal Medicine, Medical Oncology/Medical Oncology

Fellowship: Georgetown University School of Medicine GME (1993)

Fellowship: McGill University (1992)

Residency: McGill University Faculty of Medicine (1990)

Internship: Montreal General Hospital (1988)

Medical School: McGill University (1987)

Awards

  • Washingtonian Top Doc 2025 America’s Top Doctors for Women, Women’s Health Magazine
  • Marquis Who’s Who in America            
  • America’s Top Doctors, Castle Connolly
  • Newsweek’s Top Cancer Doctors
  • Top Doctors Washington DC, Washingtonian Magazine
  • Global Directory Top Doctors
  • Global Directory of Who’s Who
  • Top Doctors Washington DC Area, Northern Virginia Magazine
  • Estelle Ramey Mentorship Award, Georgetown University School of Medicine

Ratings and reviews

  • Explanations the care provider gave you about your problem or condition

    4.9
  • Extent to which the care provider listened to you

    4.9
  • Care provider’s discussion of any proposed treatment (options, risks, benefits, etc.)

    4.9
  • Provider included you in decisions

    4.9
  • Concern the care provider showed for your questions or worries

    4.9
  • Likelihood of recommending this care provider to others

    4.9
  • May 26, 2026

    Dr. Isaacs is amazing. She gives me excellent advice, time, expertise, and care. I trust her implicitly.

  • May 22, 2026

    Excellent doctor and person. I really appreciated very much her care and concerns throughout these five years of cancer treatment.

  • Apr 18, 2026

    Dr Isaacs is a compassionate, thoughtful and supportive professional practitioner who uses her expertise with confident ease