Louis M. Weiner, MD| Gastrointestinal Medical Oncology, Medical Oncology | MedStar Health

Louis M. Weiner, MD
Provider is directly employed by MedStar Health

4.8 out of 5 (78 reviews)

Specialities: Gastrointestinal Medical Oncology, Medical Oncology

Languages: English


About me

Dr. Weiner is an internationally-recognized medical oncologist specializing in gastrointestinal cancers. He is also an accomplished researcher developing novel immunotherapy treatments – essentially triggering the body’s own immune system to identify and destroy cancer. He is recognized for his laboratory and clinical research focusing on these new therapeutic approaches. Dr. Weiner wants to understand why some tumors become resistant to therapy and other forms of cancer immunotherapy, with the goal of developing new treatments to overcome that resistance. He lectures extensively on these forms of targeted therapies, which block the growth and spread of cancer.

He serves as director of the Georgetown Lombardi Comprehensive Cancer Center – Washington, D.C.’s only National Cancer Institute-designated comprehensive cancer center – and the MedStar Georgetown Cancer Institute, which combines medical expertise, the latest therapies, and research across MedStar Health throughout the region. Dr. Weiner is also associate vice president at Georgetown University Medical Center, chair of the oncology department at Georgetown University School of Medicine, and clinical director of cancer services at MedStar Georgetown University Hospital.

In these roles, Dr. Weiner is responsible for operations, development, research, clinical and educational missions. As the Institute’s director, he oversees the clinical operations of the MedStar Health cancer service line, and leads the advancement of clinical care and research programs spanning prevention, treatment, rehabilitation, survivorship and end-of-life care across the region. With Georgetown Lombardi serving as the Institute’s “research engine,” patients throughout the region have access to unmatched expertise and clinical trials closer to where they live and work.

Dr. Weiner previously served as chairman of the Medical Oncology Department and vice president for Translational Research at Fox Chase Cancer Center in Philadelphia, PA. He held an endowed chair in medical science and was the driving force behind developing an immunotherapy laboratory and clinical programs, as well as establishing the Center's medical oncology fellowship program. Dr. Weiner also served as professor in the Department of Medicine at Temple University School of Medicine.

Dr. Weiner's Philosophy of Care
We live in a time of great hope in the area of cancer therapy. Many new, important and life-changing treatments are now being developed. We are privileged to offer patients tomorrow's treatments today. And now, through the MedStar Georgetown Cancer Institute, we can extend that mission across the region. With this progress in mind, I strive to offer all my patients the best possible therapies for their diseases, always mindful that I am neither treating a disease nor a patient, but a person with a life, a family and a combination of hopes and fears.

Working at a great cancer program like this gives me the opportunity to collaborate with leading international experts to assure that my patients can benefit from the best possible care during the course of their journeys.

Clinical areas of focus

  • Colorectal Malignancy
  • Esophageal Cancer
  • Gastrointestinal (GI) Cancer
  • Gastrointestinal (GI) Stromal Tumors
  • Hepatoblastoma
  • Liver Cancer
  • Liver Metastases
  • Pancreas Cancer
  • Rectal Cancer
  • Small Bowel Cancer
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Conditions and procedures

Conditions I treat

  • Abdominal Cancer
  • Anal Cancer
  • Anorectal Cancer
  • Appendiceal Cancer
  • Bile Duct Mass
  • Brca
  • Cancer
  • Cancer During Pregnancy
  • Cancer Pain
  • Cancer Related Fatigue
  • Cancer Survivor
  • Carcinoid Of Stomach
  • Carcinoid Tumor
  • Carcinoid Tumor Of Pancreas
  • Cholangiocarcinoma
  • Colorectal Malignancy
  • Cystadenoma Of Pancreas
  • Endocrine Complications Of Cancer Therapy
  • Esophageal Cancer
  • Gallbladder Cancer
  • Gastrin Secreting Tumor Of Pancreas
  • Gastroesophageal Junction Cancer
  • Gastrointestinal (GI) Cancer
  • Gastrointestinal (GI) Stromal Tumors
  • Head And Neck Tumors
  • Hepatobiliary Malignancies
  • Hepatoblastoma
  • Hereditary Cancer Risk
  • Insulinoma
  • Islet Cell Tumor
  • Kras Mutation
  • Liver Cancer
  • Liver Mass
  • Liver Metastases
  • Lung Mass
  • Lynch Syndrome
  • Malignant Neoplasm Of Pancreatic Duct
  • Malignant Rectal Neoplasm
  • Malignant Tumor Of Extrahepatic Bile Duct
  • Metastatic Colon Cancer
  • Neuroendocrine Tumors
  • Oral Complications Of Cancer
  • Pancreas Cancer
  • Pancreas Head Cancer
  • Pancreas Tail Cancer
  • Pancreatic Mass
  • Pseudomyxoma Peritonei
  • Pulmonary Metastases
  • Rectal Cancer
  • Rectal Carcinoma In Situ
  • Recurrent Colorectal Cancer
  • Side Effects Of Cancer Treatment
  • Small Bowel Cancer
  • Small Intestine Cancer
  • Stomach Cancer
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Procedures I perform

  • Adjuvant Chemotherapy
  • Biologic Therapy For Gastrointestinal Diseases
  • Biological Targeted Therapy
  • Cancer Chemotherapy
  • Cancer Genomics
  • Chemoradiation
  • Colon Cancer Chemotherapy
  • Early Detection Of Cancer
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Practice locations

Distance from Change LocationEnter your Location

3800 Reservoir Road Northwest
Lombardi Cancer Center
Washington, DC, 20007


Fax 866-495-1112

Get Directions

miles away

Fax 866-495-1112


MedStar Medical Group accepts most major health insurance plans. If you are uncertain as to whether your individual health insurance plan is accepted at MedStar Medical Group, please call your insurance company.

  • List of insurance plans we accept
    • Aetna Elect Choice/ EPO (Aetna Health Fund) Innovation Health: Network Only Plus
    • Aetna Quality Point of Service (POS)
    • Aetna USAccess (POS)
    • Aetna Student Health Insurance
    • Aetna Medicare Advantage HMO & PPO Plans
    • CFBCBS BlueChoice HMO
    • CFBCBS Blue Choice Opt Out Plus Open Access (POS)
    • CFBCBS Maryland Point of Service Plan (MPOS)
    • CFBCBS Federal Employee Program (Std. & Basic PPO)
    • CFBCBS Maryland Indemnity or PPO
    • CFBCBS (NCA) Indemnity
    • CIGNA HMO & Network (HMO)
    • CIGNA POS/Network POS
    • Great-West Healthcare POS/CIGNA
    • CIGNA Indemnity
    • Coventry Health Care of Virginia
    • Coventry of Delaware HMO/PPO
    • First Health PPO
    • Tricare Prime
    • Tricare Standard
    • Tricare Extra (Indemnity)
    • Tricare for Life (Medicare Supplemental Plan)
    • MedStar Family Choice - Maryland Health Choice
    • MedStar Select (MedStar Associates' Plan)
    • MedStar Medicare Choice
    • United Healthcare Select HMO - EPO/NPP
    • United Healthcare Select Plus (POS)
    • United Healthcare Choice Plus
    • United Student Resources
    • M.D. IPA (HMO)
    • M.D. IPA Preferred (POS)
    • Optimum Choice Preferred (POS) & OCI Direct (HMO)
    • Mamsi Life & Health (Indem./PPO)
    • Aetna Worker's Compensation Network
    • Coventry Health Care National Network PPO
    • Private Health Care Systems (PHCS) (PPO)
    • United Healthcare Options (PPO) (includes Empire PPO, GEHA, Compass Rose)
    • OneNet PPO, Inc.
    • United Healthcare Choice
    • United Healthcare Core Essential (HMO)
    • Optimum Choice
    • United Healthcare Navigate
    • United Healthcare Compass (HMO)
    • CIGNA HMO Open Access (OA)
    • Network OA
    • POS OA & OA Plus
    • PPO and PPO Plus
    • Choice Fund PPO
    • CFBSBC Blue Preferred PPO
    • HealthyBlue PPO
    • CFBCBS Blue Choice Opt Out Open Access
    • BlueChoice Open Access
    • Blue Choice Advantage & Healthy Blue (HMO, POS)
    • Aetna Traditional Choice (PPO)
    • Innovation Health: Indemnity
    • Aetna Open Choice (PPO)
    • Innovation Health: PPO
    • Aetna Managed Choice (POS)
    • Innovation Health: POS Plus
    • Aetna Elect Choice/ Open Access (POS)
    • Innovation Health: Open Network Only Plus
    • Aetna HMO-Open Access/Select OA/HealthFund/Health Network Option OA
    • Innovation Health: POS
    • Open HMO
    • Opoen HMO Option
    • Open EPO Plus
    • Aetna Managed Choice Open Access (POS)
    • Choice POS & Choice POS II
    • Innovation Health: Open POS Plus
    • Open POS II
    • Aetna HMO
    • Select HMO/HealthFund/Health Network
    • Aetna Innovations: HMO & EPO Plus



Board Certification: American Board of Internal Medicine, Medical Oncology

Board Certification: American Board of Internal Medicine, Internal Medicine

Fellowship Program: New England Medical Center Hospitals (1982)

Residency Program: Fletcher Allen Health Care (1981)

Internship Program: Fletcher Allen Health Care (1978)

Medical School: Mount Sinai School of Medicine (1977)


  • Castle Connolly Top Doctors, 2021
  • National Academy of Inventors Fellow, 2017-2018
  • Recognition for Outstanding Contribution to Innovation and Commercialization, Georgetown University, Office of Technology, 2016
  • Fellow, American College of Physicians, 2010
  • America’s Top Oncologists, 2009               
  • America’s Top Doctors for Cancer, 2007 – Present
  • Philadelphia Magazine's Top Docs, 2002; 2004 – 2007
  • Who's Who in Medicine and Healthcare, 2002 - 2005
  • G. Morris Dorrance, Jr. Endowed Chair in Medical Science, 2002
  • American Association for Cancer Research Scientist-Survivor Program Award, 2002
  • American Cancer Society - Southeast Region Scientific Research Award, 2002
  • Janssen Pharmaceutical Research Foundation: Research Award for Outstanding Contributions to the Field of Receptor Targeted Therapy, 2001
  • Best Doctors in America, 2000-2011
  • National Cancer Institute Clinical Investigator Award, 1986
  • American Cancer Society Career Development Award, 1985

News and publications

Dr. Weiner has authored more than 200 publications throughout his career centering on the following core topics:

Enhancing Antibody Dependent Cellular Cytotoxicity (ADCC) as an Anti-Tumor Mechanism

Manipulating Antibody Structure to Improve Selective Tumor Targeting

Identifying Tumor Cell-Based Determinants of Antibody-Mediated Cell Killing

Immunoconjugates for Cancer Therapy

Antibody-initiated Cancer Immunotherapy

Click here for a complete list of his research papers and scientific contributions. 

Ratings and reviews

  • Provider explained things understandably

  • Provider listened carefully

  • Provider knew medical history

  • Provider showed respect

  • Provider spent enough time with patient

  • Feb 3, 2022

    The medical clinic record did not accurately reflect what was done on physical exam by the provider. No rectal exam done, but record reflected it was done.

  • Mar 4, 2021

    Dr. Weiner is truly a truly remarkable Dr. He makes talking to him so easy.

  • Oct 29, 2020

    All in all care provided by Dr. Weiner & staff very good.