Louis M. Weiner, MD| Gastrointestinal Medical Oncology, Medical Oncology | MedStar Health

Louis M. Weiner, MD
Provider is directly employed by MedStar Health

4.8 out of 5 (99 reviews)

Specialties: Gastrointestinal Medical Oncology, Medical Oncology

Languages: English


About me

Dr. Weiner is an internationally-recognized medical oncologist specializing in gastrointestinal cancers. He is also an accomplished researcher developing novel immunotherapy treatments – essentially triggering the body’s own immune system to identify and destroy cancer. He is recognized for his laboratory and clinical research focusing on these new therapeutic approaches. Dr. Weiner wants to understand why some tumors become resistant to therapy and other forms of cancer immunotherapy, with the goal of developing new treatments to overcome that resistance. He lectures extensively on these forms of targeted therapies, which block the growth and spread of cancer.

He serves as director of the Georgetown Lombardi Comprehensive Cancer Center – Washington, D.C.’s only National Cancer Institute-designated comprehensive cancer center – and the MedStar Georgetown Cancer Institute, which combines medical expertise, the latest therapies, and research across MedStar Health throughout the region. Dr. Weiner is also associate vice president at Georgetown University Medical Center, chair of the oncology department at Georgetown University School of Medicine, and clinical director of cancer services at MedStar Georgetown University Hospital.

In these roles, Dr. Weiner is responsible for operations, development, research, clinical and educational missions. As the Institute’s director, he oversees the clinical operations of the MedStar Health cancer service line, and leads the advancement of clinical care and research programs spanning prevention, treatment, rehabilitation, survivorship and end-of-life care across the region. With Georgetown Lombardi serving as the Institute’s “research engine,” patients throughout the region have access to unmatched expertise and clinical trials closer to where they live and work.

Dr. Weiner previously served as chairman of the Medical Oncology Department and vice president for Translational Research at Fox Chase Cancer Center in Philadelphia, PA. He held an endowed chair in medical science and was the driving force behind developing an immunotherapy laboratory and clinical programs, as well as establishing the Center's medical oncology fellowship program. Dr. Weiner also served as professor in the Department of Medicine at Temple University School of Medicine.

Dr. Weiner's Philosophy of Care
We live in a time of great hope in the area of cancer therapy. Many new, important and life-changing treatments are now being developed. We are privileged to offer patients tomorrow's treatments today. And now, through the MedStar Georgetown Cancer Institute, we can extend that mission across the region. With this progress in mind, I strive to offer all my patients the best possible therapies for their diseases, always mindful that I am neither treating a disease nor a patient, but a person with a life, a family and a combination of hopes and fears.

Working at a great cancer program like this gives me the opportunity to collaborate with leading international experts to assure that my patients can benefit from the best possible care during the course of their journeys.

Clinical areas of focus

  • Colorectal Malignancy
  • Esophageal Cancer
  • Gastrointestinal (GI) Cancer
  • Gastrointestinal (GI) Stromal Tumors
  • Hepatoblastoma
  • Liver Cancer
  • Liver Metastases
  • Pancreas Cancer
  • Rectal Cancer
  • Small Bowel Cancer
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Conditions and procedures

Conditions I treat

  • Abdominal Cancer
  • Anal Cancer
  • Anorectal Cancer
  • Appendiceal Cancer
  • Bile Duct Mass
  • Brca
  • Cancer
  • Cancer During Pregnancy
  • Cancer Pain
  • Cancer Related Fatigue
  • Cancer Survivor
  • Carcinoid Of Stomach
  • Carcinoid Tumor
  • Carcinoid Tumor Of Pancreas
  • Cholangiocarcinoma
  • Colorectal Malignancy
  • Cystadenoma Of Pancreas
  • Endocrine Complications Of Cancer Therapy
  • Esophageal Cancer
  • Gallbladder Cancer
  • Gastrin Secreting Tumor Of Pancreas
  • Gastroesophageal Junction Cancer
  • Gastrointestinal (GI) Cancer
  • Gastrointestinal (GI) Stromal Tumors
  • Head And Neck Tumors
  • Hepatobiliary Malignancies
  • Hepatoblastoma
  • Hereditary Cancer Risk
  • Insulinoma
  • Islet Cell Tumor
  • Kras Mutation
  • Liver Cancer
  • Liver Mass
  • Liver Metastases
  • Lung Mass
  • Lynch Syndrome
  • Malignant Neoplasm Of Pancreatic Duct
  • Malignant Rectal Neoplasm
  • Malignant Tumor Of Extrahepatic Bile Duct
  • Metastatic Colon Cancer
  • Neuroendocrine Tumors
  • Oral Complications Of Cancer
  • Pancreas Cancer
  • Pancreas Head Cancer
  • Pancreas Tail Cancer
  • Pancreatic Mass
  • Pseudomyxoma Peritonei
  • Pulmonary Metastases
  • Rectal Cancer
  • Rectal Carcinoma In Situ
  • Recurrent Colorectal Cancer
  • Side Effects Of Cancer Treatment
  • Small Bowel Cancer
  • Small Intestine Cancer
  • Stomach Cancer
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Procedures I perform

  • Adjuvant Chemotherapy
  • Biologic Therapy For Gastrointestinal Diseases
  • Biological Targeted Therapy
  • Cancer Chemotherapy
  • Cancer Genomics
  • Chemoradiation
  • Colon Cancer Chemotherapy
  • Early Detection Of Cancer
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Practice locations

Distance from Change LocationEnter your Location

3800 Reservoir Road Northwest
Lombardi Cancer Center
Washington, DC, 20007


Fax 202-444-1229

Get Directions

miles away

Fax 202-444-1229


MedStar Health accepts most major health insurance plans. If you are uncertain as to whether your individual health insurance plan is accepted at MedStar Health, please call your insurance company.

  • List of insurance plans we accept
    • Aetna Better Health of Maryland
    • Cigna HealthSpring Medicare Advantage
    • UnitedHealthcare and AARP Medicare Complete Plans/ UHC Group Medicare Advantage Plans HMO, POS, PPO
    • United Healthcare Options (PPO) (includes Empire PPO, GEHA, Compass Rose)
    • Blue Choice Advantage & Healthy Blue (HMO, POS)
    • Kaiser Permanente Signature-Added Choice
    • UHC Community Plan of MD
    • Private Health Care Systems (PHCS) (PPO)
    • Kaiser Permanente Select
    • Kaiser MD Medicaid MCO
    • UnitedHealthcare Medicare Adv/Special Needs Plans
    • Kaiser Permanente Flexible Choice POS
    • Kaiser PermanenteSelect-Added Choice
    • Kaiser Permanente Signature
    • Kaiser Permanente Medicare Plus (Medicare Supplemental Plan)
    • CFBCBS Federal Employee Program (Std/Basic PPO/Blue Focus)
    • Medicare Fee for Service
    • Kaiser Virginia Premier
    • CFBCBS Blue Choice Opt Out Open Access
    • Innovation Health: Indemnity
    • Open EPO Plus
    • Choice Fund PPO
    • Aetna Managed Choice Open Access (POS)
    • United Healthcare Choice
    • POS OA & OA Plus
    • Innovation Health: POS Plus
    • Innovation Health: POS
    • Innovation Health: Open POS Plus
    • CIGNA HMO Open Access (OA)
    • HealthyBlue PPO
    • Innovation Health: PPO
    • Aetna Innovations: HMO & EPO Plus
    • Aetna HMO-Open Access/Select OA/HealthFund/Health Network Option OA
    • Choice POS & Choice POS II
    • Open POS II
    • Innovation Health: Open Network Only Plus
    • BlueChoice Open Access
    • Opoen HMO Option
    • Select HMO/HealthFund/Health Network
    • Aetna HMO
    • Network OA
    • Aetna Traditional Choice (PPO)
    • PPO and PPO Plus
    • Open HMO
    • CFBSBC Blue Preferred PPO
    • Aetna Managed Choice (POS)
    • Aetna Open Choice (PPO)
    • Aetna Elect Choice/ Open Access (POS)
    • Coventry Health Care National Network PPO
    • Aetna Worker's Compensation Network
    • Mamsi Life & Health (Indem./PPO)
    • Optimum Choice Preferred (POS) & OCI Direct (HMO)
    • M.D. IPA Preferred (POS)
    • M.D. IPA (HMO)
    • United Student Resources
    • United Healthcare Choice Plus
    • United Healthcare Select Plus (POS)
    • United Healthcare Select HMO - EPO/NPP
    • MedStar Select (MedStar Associates' Plan)
    • MedStar Family Choice - Maryland Health Choice
    • Tricare for Life (Medicare Supplemental Plan)
    • Tricare Prime
    • First Health PPO
    • Coventry of Delaware HMO/PPO
    • Coventry Health Care of Virginia
    • CIGNA Indemnity
    • Great-West Healthcare POS/CIGNA
    • CIGNA POS/Network POS
    • CIGNA HMO & Network (HMO)
    • CFBCBS (NCA) Indemnity
    • CFBCBS Maryland Indemnity or PPO
    • CFBCBS Maryland Point of Service Plan (MPOS)
    • CFBCBS Blue Choice Opt Out Plus Open Access (POS)
    • CFBCBS BlueChoice HMO
    • Aetna Medicare Advantage HMO & PPO Plans
    • Aetna Student Health Insurance
    • Aetna Quality Point of Service (POS)
    • Aetna Elect Choice/ EPO (Aetna Health Fund) Innovation Health: Network Only Plus



Board Certification: American Board of Internal Medicine, Medical Oncology

Board Certification: American Board of Internal Medicine, Internal Medicine

Fellowship Program: New England Medical Center Hospitals (1982)

Residency Program: Fletcher Allen Health Care (1981)

Internship Program: Fletcher Allen Health Care (1978)

Medical School: Mount Sinai School of Medicine (1977)


  • Castle Connolly Top Doctors, 2021
  • National Academy of Inventors Fellow, 2017-2018
  • Recognition for Outstanding Contribution to Innovation and Commercialization, Georgetown University, Office of Technology, 2016
  • Fellow, American College of Physicians, 2010
  • America’s Top Oncologists, 2009               
  • America’s Top Doctors for Cancer, 2007 – Present
  • Philadelphia Magazine's Top Docs, 2002; 2004 – 2007
  • Who's Who in Medicine and Healthcare, 2002 - 2005
  • G. Morris Dorrance, Jr. Endowed Chair in Medical Science, 2002
  • American Association for Cancer Research Scientist-Survivor Program Award, 2002
  • American Cancer Society - Southeast Region Scientific Research Award, 2002
  • Janssen Pharmaceutical Research Foundation: Research Award for Outstanding Contributions to the Field of Receptor Targeted Therapy, 2001
  • Best Doctors in America, 2000-2011
  • National Cancer Institute Clinical Investigator Award, 1986
  • American Cancer Society Career Development Award, 1985

News and publications

Dr. Weiner has authored more than 200 publications throughout his career centering on the following core topics:

  • Enhancing Antibody Dependent Cellular Cytotoxicity (ADCC) as an Anti-Tumor Mechanism

  • Manipulating Antibody Structure to Improve Selective Tumor Targeting

  • Identifying Tumor Cell-Based Determinants of Antibody-Mediated Cell Killing

  • Immunoconjugates for Cancer Therapy

  • Antibody-initiated Cancer Immunotherapy

  • Click here for a complete list of his research papers and scientific contributions. 

Ratings and reviews

  • Explanations the care provider gave you about your problem or condition

  • Extent to which the care provider listened to you

  • Care provider's discussion of any proposed treatment (options, risks, benefits, etc.)

  • Care provider's efforts to include you in decisions about your care

  • Concern the care provider showed for your questions or worries

  • Likelihood of recommending this care provider to others

  • Jun 1, 2023

    I have recommend to others.

  • Feb 23, 2023

    Dr. Weiner has been a source of security for over 10 years now that everything is under control!

  • Dec 1, 2022

    Dr. Weiner was easy to talk to and answered all my questions to my satisfaction.