Diego A. Medvedofsky

Diego A. Medvedofsky, MD, is the associate director of Cardiac Imaging Research and a physician scientist at the Cardiovascular Core Laboratory, MedStar Health Research Institute and MedStar Washington Hospital Center. Dr. Medvedofsky specializes in cardiac imaging.

His areas of research include three-dimensional (3D) echocardiography, myocardial deformation (strain) analysis, contrast echocardiography, computed tomography, magnetic resonance imaging, and the role of cardiac imaging in valvular heart disease and heart failure. He is currently focusing his research efforts on myocardial deformation (strain) analysis. Specifically, he is collaborating to incorporate the use of strain methodologies in transcatheter device placement to treat mitral regurgitation, transcatheter aortic valve replacement, and potential treatments for patients with advanced heart failure.

Dr. Medvedofsky has published his research on novel approaches to cardiac imaging in more than 30 articles in peer-reviewed journals, including the Journal of the American College of Cardiology, Journal of the American Society of Echocardiography, Journal of Cardiac Failure, Hypertension, Journal of Cardiology, American Journal of Cardiology, and others. In addition, he reviews manuscripts for Catheterization and Cardiovascular Interventions and Cardiovascular Revascularization Medicine. Dr. Medvedofsky is fluent in English, Spanish, and Hebrew.

His medical degree is from the University of Buenos Aires Medical School. He completed a residency in internal medicine at Meir General Hospital and a fellowship in cardiology at Sheba Medical Center, both in Israel. He then completed a 3-year fellowship in advanced non-invasive cardiac imaging at the University of Chicago Medical Center.

Research Interests

Dr. Medvedofsky’s research interests include the following:

  • 3D echocardiography, including volumetric analysis, automaticity, strain, rotational mechanics, shape, and dynamic assessment
  • Myocardial deformation (strain) analysis
  • Contrast echocardiography
  • Cardiac computed tomography
  • Cardiac magnetic resonance imaging
  • Cardiovascular devices
  • Novel approaches to cardiac imaging

Selected Research 

2D and 3D Echocardiography-Derived Indices of Left Ventricular Function and Shape: Relationship with Mortality


In this study, Dr. Medvedofsky and colleagues showed the improved performance of 3D over 2D echocardiography for left ventricular volumetric assessment and the advantage of 2D and 3D left ventricular longitudinal strain analysis over ejection fraction. Three-dimensional shape analysis provided additional risk information. This work has been published in JACC: Cardiovascular Imaging (2017, Nov 10. Doi: 10.1016/j.jcmg.2017.08.023).


3D Echocardiographic Quantification of the Left-Heart Chambers Using an Automated Adaptive Analytics Algorithm


Dr. Medvedofsky led this multinational trial to validate a new automated 3D echocardiographic volumetric analysis. The results of this work have been published in European Heart Journal Cardiovascular Imaging (2018;19:47-58).


3D Echocardiographic Quantification of Right Ventricular Volume and Function


Echocardiographic assessment of the right ventricle is challenging because of its complex shape. Dr. Medvedofsky and colleagues have described the acquisition and analysis of a new approach for volumetric assessment in the Journal of the American Society of Echocardiography (2015;28:1222-1231).


View Dr. Medvedofsky's publications on PubMed. 

Research Areas

  • Cardiovascular
    Core Services