Gholam K. Motamedi, MD, is a professor and director of the Comprehensive Epilepsy Center in the Department of Neurology at MedStar Georgetown University Hospital. Dr. Motamedi chose his specialty because he feels that neuroscience is at the frontier of science. His philosophy of care involves undertaking a comprehensive work-up, making the correct diagnosis and administering the most efficient treatment possible for the patient.
Dr. Motamedi has published numerous original research studies, reviews and has contributed several book chapters to works in the fields of epilepsy and sleep disorders. Some of his research studies include investigating potentially therapeutic effects of direct brain stimulation in patients with epilepsy, potentially therapeutic effects of direct brain stimulation and brain cooling (hypothermia) in animal models of epilepsy, basic cellular and molecular mechanisms underlying the development of epilepsy, particular genetic forms of epilepsy mimicking sleep disorders, sleep apnea, monitoring cardiac telemetry and pulse oximetry in patients with epilepsy undergoing continuous video-EEG monitoring and retrospective study of in utero antiepileptic drug effects on neurodevelopment. Dr. Motamedi has also received several awards for excellence in patient treatment, teaching and research.
Professional Association Memberships
American Epilepsy Society
American Academy of Sleep Medicine
American Neurological Association
- Fellowship Program: Johns Hopkins Hospital (2001)
- Residency Program: Baylor College of Medicine Affiliated Hospitals (1998)
- Residency Program: Do not use-Baylor College of Medicine (1998)
- Residency Program: University of Missouri Medical Center (1996)
- Residency Program: Univ. of Med & Dentistry of N.J. (1996)
- Internship Program: Yale New Haven Hospital (1995)
- Residency Program: Yale New Haven Hospital (1995)
- Internship Program: Yale-New Haven Hospital (1995)
- Medical School: Tehran University of Medical Sciences (1987)
- Board Certification: American Board of Psychiatry and Neurology, Neurology
- Board Certification: American Board of Psychiatry and Neurology, Clinical Neurophysiology
Stevens JM, Levine MR, Constantino AE, Motamedi GK. Case of fatal familial insomnia caused by a d178n mutation with phenotypic similarity to Hashimoto's encephalopathy. BMJ Case Rep. 2018 Jul 15;2018. DOI: 10.1136/bcr-2018-225155. PMID: 30012679.
Oyegbile T, Santos C, Zecavati N, Berkowitz F, Lee C, Motamedi G, VanMeter J, Gaillard WD, Hermann B. Executive Dysfunction is Associated with an Altered Executive Control Network in Pediatric Temporal Lobe Epilepsy. Epilepsy & Behavior. 2018 Sep;86:145-152. DOI: 10.1016/j.yebeh.2018.04.022. PMID: 30001910.
Anyanwu C, Motamedi GK. Diagnosis and Surgical Treatment of Drug-Resistant Epilepsy. Brain Sci. 2018, 8(4), 49 doi:10.3390/brainsci8040049.
Cho YW, Kang MS, Kim KT, Moon HG, Korostyshevskiy VP, Motamedi GK, Yang KI. Comorbid Insomnia with obstructive sleep apnea: clinical characteristics and risk factors. J Clin Sleep Med. 2018;14(3):409417. DOI:10.5664/jcsm.6988. PMID: 29458695.
Cho YW, Kang MS, Kim KT, Do SY, Lim JG, Lee SY, Motamedi GK. Quantitative sensory test for primary restless legs syndrome/Willis-Ekbom Disease (RLS/WED) Using the Current Perception Threshold Test. J Clin Sleep Med. 2017 Feb;30:19-23. PMID: 28215248.
Kim KT, Motamedi GK, Cho YW. Quality of life in patients with an idiopathic rapid eye movement sleeps behavior disorder in Korea. J Sleep Research. 2016 Dec 26. doi: 10.1111/jsr.12486. PMID: 28019055.
Wickwire EM, Williams SG, Roth T, Capaldi VF, Jaffe M, Moline M, Motamedi GK, Morgan GW, Mysliwiec V, Germain A, Pazdan RM, Ferziger R, Balkin TJ, MacDonald ME, Macek TA, Yochelson MR, Scharf SM, Lettieri CL. Sleep, sleep disorders, and mild traumatic brain injury - What we know and what we need to know: Findings from a national working group. Neurotherapeutics. 2016 Apr;13(2):403-17.
Vitantonio D, Xu W, Geng X, Takagaki K, Motamedi GK, Wu JY. Emergence of dominant initiation sites for interictal spikes in rat neocortex. J Neurophysiol. 2015 Oct 7.
Kim KT, Cho, M.D YW, Kim DE, M.D, Hwang SH, Song ML, Motamedi GK. Two Subtypes of Positional Obstructive Sleep Apnea: Supine-predominant and Supine-isolated OSA. Clinical Neurophysiology. 2015 Jun 16.
Motamedi GK, Wheeler MG. Daily episodes of confusion altered behavior · chronic sleep deprivation · Dx? J Fam Pract. 2015 Feb;64(2):92-6.
Takagaki K, Morales MK, Vitantonio D, Berkowitz F, Bell WL, Kumar PN, Motamedi GK. Periodic lateralized epileptiform discharges (PLEDs) in patients with neurosyphilis and HIV infection. Clin EEG Neurosci. 2014 Oct 17.
Takagaki K, Russell J, Lippert MT, Motamedi GK. Interhemispheric delay of alpha phase in autistic children. Clinical Neurophysiology. 2014 May 27.
Vallabhaneni M, Baltassari L, Scribner JT, Cho YW, Motamedi GK. Wicket Spikes in Patients Undergoing Long-term Video-EEG Monitoring. Seizure, The European Journal of Epilepsy, 22 (2013) 14–19.
Anyanwu C, Ghavami F, Schuelein M, Motamedi GK. Ethosuximide-induced conversion of typical childhood absence to Rolandic spikes? J Child Neurol. 2013 Jan;28(1), pp. 109–112.
Raybould JE, Alfers C, Cho YW, Wang H, Nawar S, Epstein SA, Motamedi GK. Is EEG Screening for Temporal Lobe Epilepsy in Patients with Acute Psychosis warranted? J Neuropsychiatry Clin Neurosci. 2012 Sep 1;24(4):452-7.
Motamedi GK, Gonzalez-sulser A, Dzakpasu R, Vicini S. Cellular mechanisms of desynchronizing effects of hypothermia in an in vitro epilepsy model. Neurotherapeutics 2012 Jan;9(1):199-209.
Enkiri SA, Ghavami F, Anyanwu C, Eldadah Z, Morrissey RL, Motamedi GK. New onset left frontal lobe seizure presenting with ictal asystole. Seizure, The European Journal of Epilepsy, 2011 Dec;20(10):817-9.
Cho YW, Kim DH, Motamedi GK. The effect of levetiracetam monotherapy on subjective sleep quality and objective sleep parameters in patients with epilepsy: Compared with the effect of carbamazepine-CR monotherapy. Seizure, The European Journal of Epilepsy, 2011 May;20(4):336-9.
Gonzalez-Sulser A, Wang J, Motamedi GK, Avoli M, Vicini S, Dzakpasu R. The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array. Neuropharmacology. 2011 Jun;60(7-8):1142-53.
Ghosh P, Motamedi G, MD, Osborne B, Mora CA. Reversible Blindness: Simple Partial Seizures Presenting as Ictal and Postictal Hemianopsia. Journal of Neuro-Ophthalmology, 2010 Sep;30(3):272-5.
Cho YW, Yi SD, Motamedi GK. Frontal Lobe Epilepsy May Present as Myoclonic Seizure. Epilepsy & Behavior. 2010 Apr;17(4):561-4. Epub 2010 Feb 23.
Slezicki KI, Cho YW, Brock MS, Pfeiffer M, McVearry K, Tractenberg RE, Motamedi GK. Incidence of atypical handedness in epilepsy and its association with clinical factors. Epilepsy & Behavior. 13.2 (2008): 361-5.
Cho YW, Yi SD, Lim JG, Kim DK, Motamedi GK. Autosomal dominant nocturnal frontal lobe epilepsy and mild memory impairment associated with CHRNB2 mutation I312M in the neuronal nicotinic acetylcholine receptor (nAChR). Epilepsy & Behavior. 2008 Aug;13(2):361-5. Epub 2008 Jun 4.
Meador KJ, Gevins A, Loring DW, McEvoy LK, Ray PG, Smith ME, Motamedi GK, Evans BM. Neuropsychological and Neurophysiological Effects of Carbamazepine and Levetiracetam. Neurology 2007;69;2076-2084.
Motamedi GK, Okunola O, Kalhorn CG, Mostofi N, Mizuno‑Matsumoto Y, Cho YW, Meador KJ. Afterdischarges during cortical Stimulation at different frequencies and intensities. Epilepsy Res, 2007; 77, 65-69.
Towfigh A, Mostofi N, Motamedi GK. Post-stroke partial seizures presenting as hemifacial spasm. Mov Disord. 2007 ;22(13):1981-2.
Ortinski PI, Turner JR, Barberis A, Motamedi G, Yasuda RP, Wolfe BB, Kellar KJ, Vicini S. Deletion of the GABA(A) receptor alpha1 subunit increases tonic GABA(A) receptor current: a role for GABA uptake transporters. J Neurosci. 2006 Sep 6;26(36):9323-31.
Motamedi GK, Salazar P, Smith EL, Lesser RP, Webber WR, Ortinski PI, Vicini S, Rogawski MA. Terrmination of epileptiform activity by cooling in rat hippocampal slice epilepsy models. Epilepsy Res. 2006 Aug;70(2-3):200-10. Epub 2006 Jul 3.
Motamedi GK, Meador KJ. Antiepileptic Drugs and Neurodevelopment. Curr Neurol Neurosci Rep. 2006 Jun;6(4):341-6.
Mizuno-Matsumoto Y, Motamedi GK, Webber WRS, Ishii R, Ukai S, Kaishima T, Shinosaki K, Lesser RP. Wavelet-crosscorrelation analysis of electrocorticography recordings from epilepsy. International Congress Series 1278 (2005) 411–414.
Mizuno-Matsumoto Y, Motamedi GK, Webber WRS, Ukai S, Date S, Kaishima T, Takeda M, Shimojo S, Inoue T, Lesser RP. Effectiveness of brief bursts of pulse stimulation to terminate afterdischarges. "Rinsyou Nouha" Japanese Clinical Electroencephalography. 2003: Vol.45 no.12:773-777.
Cho YW, Motamedi GK, Laufenberg I, Sohn SI, Lim JG, Lee H, Yi SD, Lee H, Kim DK, Reba R, Gaillard WD, Theodore WH, Lesser RP, Steinlein OK. A Korean Kindred with Autosomal Dominant Nocturnal Frontal Lobe Epilepsy and Mental Retardation. Arch Neurol. 2003;60:1625-1632.
Motamedi GK, Lesser RP, Miglioretti DL, Mizuno-Matsumoto Y, Gordon B, Webber WRS, Jackson DC, Sepkuty JP, Crone NC. Optimizing parameters for terminating afterdischarges with electrical stimulation of the cortex. Epilepsia 2002, Aug;43(8):836-46.
Motamedi GK, Lesser RP. Autosomal dominant nocturnal frontal lobe epilepsy. Adv Neurol. 2002;89:463-73.
Mizuno-Matsumoto Y, Motamedi GK, Webber WR, Lesser RP. Wavelet-crosscorrelation analysis can help predict whether bursts of pulse stimulation will terminate afterdischarges. Clin Neurophysiol 2002 Jan;113(1):33-42.
Motamedi GK. Psychogenic nonepileptic seizures: A disconnect between mind and body. Epilepsy & Behavior. 2018 Jan;78:293-294. PMID: 29239801.
Motamedi GK. Obstructive sleep apnea; is it the anatomy or physiology?. Clinical Neurophysiology, 125 (2014) 1717–1718.
Motamedi GK, Lesser RP, Vicini S. Therapeutic brain hypothermia, its mechanisms of action, and its prospects as a treatment for epilepsy. Epilepsia, 54(6):959–970, 2013.
Anyanwu C, Motamedi GK. Management of pediatric refractory epilepsy. Journal of Pediatric Epilepsy 1 (2012) 203–209.
Motamedi GK, Meador KJ. Antiepileptic drugs and memory. Epilepsy and Behavior. 2004 Aug;5(4):435-9.
Motamedi G, Meador K. Epilepsy and cognition. Epilepsy & Behavior. 2003 Oct;4 Suppl 2:25-38.
Motamedi GK, Noebels JL. Management of status epilepticus. Resident & Staff Physician. Special issue, Sep. 1998:12-19.
Motamedi GK, Gotman J, Lesser RP. Technical and practical aspects of invasive recordings and brain stimulation. In: Lhatoo, Sam; Kahane, Philippe; Lüders, Hans, Editors. Invasive Studies of the Human Epileptic Brain: Principles and Practice of Invasive Brain Recordings and Stimulation in Epilepsy. Oxford University Press;1st Edition, 2018. In Press.
Anyanwu C, Motamedi GK. Diagnosis and surgical treatment of epilepsy. In: Boling, Warren, Editor. Diagnosis and Surgical Treatment of Epilepsy. Brain Sciences; 1st Edition, 2018.
Motamedi, GK. Epilepsy surgery and neurostimulation. In: Koubeissi MZ, Editor. Epilepsy Board Review: A Comprehensive Guide. DeveD, Inc. In Press.
Motamedi GK, Lesser RP. Familial and Sporadic Nocturnal Frontal Lobe Epilepsy (NFLE) - Electroclinical Features. In: Osorio I, Zaveri HP, Frei MG, Arthurs S, Editors. Epilepsy: The Intersection of Neurosciences, Biology, Mathematics, Engineering and Physics. CRC Press, 2011. p. 445-50.
Motamedi GK and Meador KJ. Cognition. In: Schachter SC, Holmes GL, Kasteleijn-Nolst TD, Editors. Behavioral Aspects of Epilepsy: From Bench to Bedside. Demos Medical Publishing, New York, NY; 2007:281-288.
Motamedi GK, Lesser RP: Prospects for developing electrical stimulation of the cortex for treatment of intractable seizures. In Epilepsy Surgery. Principles and Controversies. Edited by John W. Miller and Daniel L. Silbergeld. New York, NY: Taylor & Francis Group, LLC; 2006:810-819.
Motamedi GK, Lesser RP: Autosomal dominant nocturnal frontal lobe epilepsy. In Advances in Neurology, Myoclonus and Paroxysmal Dyskinesias. Edited by S. Fahn, S. Frucht, M. Hallett, D. Truong. Philadelphia, PA: Lippincott Williams & Wilkins; 2002; 89:463-73.
Motamedi GK, Zang J. Multiple Sclerosis. In Neurology, pearls of wisdom. Edited by Michael Labanowski. Boston, MA: Boston Medical Publishing Corporation; 1998:63-76.
Motamedi GK. Short GAA trinucleotide repeat expansion and late onset Friedreich's Ataxia. Case reports, Baylor Neurology Web Site, (https://www.bcm.edu/neurology/challeng/pat25/summary.html) 1998.
Motamedi GK. Neuro-cysticercosis. Case reports, Baylor Neurology Web Site, (https://www.bcm.edu/neurology/challeng/pat10/summary.html) 1997.
A Case of Fatal Familial Insomnia Caused by a D178N Mutation with Phenotypic Similarity to Hashimoto’s Encephalopathy. Stevens J, Levine M, Amjad F, Constantino A, Tornatore CS, Motamedi GK. MedStar Health Research Symposium. 2017.
Miller A, Takagaki K, Cho M, Cho YW, Motamedi GK. Characterization of High Frequency Oscillations in a Patient with Epilepsy. Annals of Neurology Vol 80 (suppl 20) 2016.
Jeon JY, Moon HJ, Motamedi GK, Cho YW. Cefepime induced encephalopathy in a tertiary medical center in Korea. Annual Meeting of the American Epilepsy Society, 2014.
Vitantonio D, Xu W, Wu J, Motamedi G. Early involvement of the contralateral cortex as a spatial organizer of the interictal spikes. American Epilepsy Society meeting, 2012.
Gonzalez-Sulser A, Vicini S, Motamedi GK, Avoli M, Dzakpasu R. Pharmacological regulation of interictal activity studied with a perforated multi-electrode array in an in vitro epilepsy model. Society for Neuroscience annual meeting, 2010.
Cho YW, Yi SD, Kim DH, Shin WC, Motamedi GK. The effect of levetiracetam monotherapy on subjective sleep quality and objective sleep parameters in patients with epilepsy, compared with the effect of carbamazepine-CR monotherapy. European Conference on Epilepsy & Society, 2010.
Motamedi GK, Gonzalez-Sulser A, David Press D, Dzakpasu R, Vicini S. Effects of cooling on synchronous epileptiform discharges in mice hippocampus and cortex recorded through a multi-electrode array (MEA). Epilepsia, 50(Suppl. 11):1–502, 2009.
VanMeter JW, Newlin DB, Renton R, Breeden A, Motamedi G, Kuch J. Using MR Spectroscopy to Measure Cortical Changes in a Pharmacological Agent in Real-Time. Organization of Human Brain Mapping. San Francisco, CA, 2009.
Motamedi GK, Partridge JG, Vicini S. Asynchronous and differential responses of the hippocampal pyramidal cells and interneurons to hypothermia. Epilepsia, 49(suppl. 7):1–498, 2008.
Slezicki KI, Cho YW, Brock MS, Pfeiffer M, McVearry K, Tractenberg RE, Motamedi GK. Assessment of handedness in patients with epilepsy. Epilepsia, 49(suppl. 7):1–498, 2008.
McVearry KM, Motamedi G, Meador K. Behavioral lateralization and prenatal exposure to antiepileptic drugs: Evidence for increased non-right hand preference. Neurotoxicology and Teratology, 30(3), 153-262.
Cho YW, Lee E, Yi SD, Zeon SK, Motamedi GK.A comparison of ictal-interictal SPECT analyzed by SPM(ISAS) and subtraction ictal SPECT coregistered with MRI (SISCOM) in patients with intractable epilepsy. European epilepsy meeting, 2008.
Motamedi GK, Rogawski MA, Vicini S. Investigating Transient Receptor Potential Vanilloid 4 (TRPV4) Channel in Termination of Epileptiform Discharges in Hippocampal Neurons by Cooling. AES annual meeting, In Press, 2007.
Cho YW, Yi S, Kim D, Shin W, Motamedi GK. Paroxysmal nocturnal dystonia (PND) and memory deficits in a Korean family with a CHRNB2 mutation I312M in the neuronal nicotinic acetylcholine receptor (nAChR). AES annual meeting, In Press, 2007.
Alfers C, Mostofi N, Karim S, Srivastava A, Scribner J, Cho YW, Meador KJ, Motamedi GK. EEG screening for temporal lobe epilepsy in patients with acute psychosis or behavioral changes. AES annual meeting, In Press, 2007.
Scribner JT, Mostofi N, Seiner S, Cho YW, Motamedi GK. Incidence of wicket spikes in patients undergoing continuous video‑EEG monitoring. AES Annual meeting, In Press, 2007.
Motamedi GK, Rogawski MA, Vicini S. Rapid Cooling Terminates Epileptiform Discharges in Hippocampal Neurons Through Synaptic and Non-Synaptic Mechanisms. Epilepsia 47 (s4), 378.
Okunola O, Cho YW, Meador KJ, Motamedi GK. Polytherapy with Levetiracetam and Lamotrigine May Be More Effective than Lamotrigine Monotherapy in Refractory Epilepsy. Epilepsia 47 (s4), 119.
Okunola O, Kalhorn C, Mizuno-Matsumoto Y, Cho YW, Meador KJ, Lesser RP, Motamedi GK. Afterdischarges during Cortical Stimulation at Different Frequencies and Intensities. Epilepsia 47 (s4), 28.
Meador KJ, Loring DW, Ray PG, Motamedi G. Cognitive and Behavioral Effects of Carbamazepine and Levetiracetam in Healthy Volunteers. American Academy of Neurology, San Diego, April, 2006.
Ortinski PI, Barberis A, Motamedi GK, Vicini S. Tonic GABA current in cerebellar granule neurons of GABAa receptor alpha1 subunit knock‑out mice. Annual meeting of Society for Neuroscience, 2005, Washington DC, Nov. 2005.
Cho YW, Motamedi GK, Lee H, Yi SD. The effects of antiepileptic drugs on thyroid hormones and Lipid profiles in the patients with epilepsy. Epilepsia, Vol. 44, Suppl. 9:276, 2003.
Lee HW, Webber WRS, Skolasky RL, Lesser RP, Motamedi GK, Mizuno-Matsumoto Y. Measures of cortical synchronization can help predict when brief pulse stimulation will suppress afterdischarges. Epilepsia, Vol. 43:349, Suppl. 7, 2002.
Cho YW, Lee JH, Yi SD, Motamedi GK, Lesser RP. Quality of life for patients with epilepsy in korea. Epilepsia, Vol. 43:94, Suppl. 7, 2002.
Cho YW, Motamedi GK, Lesser RP, Yi SD. Adverse effects of antiepileptic drugs on bone structure in women with epilepsy. The 5th European Congress on Epileptology. October 6-10, Madrid, Spain, 2002.
Lee HW, Webber WRS, Skolasky R, Beyderman L, Motamedi GK, Mizuno-Matsumoto Y, Cho YW, Lesser RP. When is brief pulse stimulation most likely to suppress afterdischarges? An approach using neighbor cross-correlation coefficient. Neurology 2002; 58 (Suppl 3): A453-4.
Smith EL, Motamedi GK, Lesser RP, Rogawski MA. Hypothermia terminates epileptiform discharges in an in vitro epilepsy model. Epilepsia, Vol.42:230, Suppl. 7, 2001.
Cho YW, Motamedi GK, Lesser RP, Sohn SI, Lim JG, Lee H, Yi SD. Autosomal Dominant Nocturnal Partial Epilepsy (ADNPE) in a Korean Kindred. Epilepsia, Vol.42:21, Suppl. 7, 2001.
Mizuno-Matsumoto Y., Lesser RP., Webber RS, Motamedi GK, Shinosaki K, Ukai S, Ishii R, Inouye K, Date S, Shimojo S, Takeda M: “Quantifying the changes of ECoG from the patients with Epilepsy using the electrical stimulation”, The 97th Annual Conference of The Japanese Society of Psychiatry and Neurology, May. 2001, Psychiatria et Neurologia Japonica, Vol. 103, No. 10, p851, 2001
Mizuno-Matsumoto Y, Lesser RP, Webber RS, Motamedi GK, Inouye K, Shinosaki K, Ukai S, Ishii R, Date S, Shimojo S, Tamura S. Takeda M: “Wavelet cross-correlation analysis can predict
whether BPS will stop AD of ECoG”. The 30th Annual Congress of the Japanese Society of Clinical Neurophysiology, Dec. 2000, Japanese Journal of Clinical Neurophysiology, Vol. 29, No. 2, p. 196, 2001
Motamedi GK, Rogawski MA, Bergey GK, Webber WRS, Lesser RP. Hippocampal stimulation to terminate epileptiform discharges in an in vitro epilepsy model. Epilepsia, Vol. 41, Suppl. 7, 2000.
Mizuno-Matsumoto Y, Lesser RP, Webber WRS, Motamedi GK, Shimojo S, Kadobayashi Y, Date S, Tamura S, Shinosaki K, Takeda M, Jonan O. Wavelet-crosscorrelation mapping can reveal how the brain conditions change with brief pulses of stimulation. Epilepsia, Vol. 41, Suppl. 7, 2000.
Mizuno-Matsumoto Y, Motamedi GK, Webber WRS, Lesser RP. "Wavelet-crosscorrelation analysis can help predict whether bursts of pulse stimulation will terminate afterdischarges". Neurology, Vol. 54. No6. Suppl 2. 2000.
Motamedi GK, Lesser RP, Miglioretti D, Gordon B, Webber WRS, Sepkuty J, Crone N. Brief pulse stimulation is more likely to terminate afterdischarges during their negative phase. Epilepsia, Vol. 40 (suppl 7):136. 1999.
Sepkuty JP, Crone NE, Hao L, Webber R, Lesser RP, and Motamedi GK. Spike-averaging reveals functional connectivity of epileptogenic zones. ABCN Annual Meeting, Oct.-Dec. 1999.
Motamedi GK, White P, Simkins R. "Evaluation of accuracy of ictal, interictal and digital subtraction single photon emission computed tomography (SPECT) in localization of temporal lobe epilepsy". Epilepsia, Vol 39. Suppl 6. 1998.
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