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Research Projects

Research Projects


Research Project 1

Intravesical Probiotic (Lactobacillus) for Urinary Symptoms Among People with Neurogenic Lower Urinary Tract Dysfunction Who Use Indwelling Catheters

The objective of this study is to:

  1. Look at healthy urine when not experiencing urinary symptoms
  2. Estimate the effect of intravesical Lactobacillus GG dose on urinary symptoms

Participants must be:

  • Diagnosed with neurogenic bladder (SCI, MS, SB, Stroke etc);
  • Use indwelling catheterization for bladder management
  • 18 years or older;
  • Have a history of 2 or more episodes of urinary symptoms in the past year.

Objective 1: Participants in the metropolitan Washington DC area will leave 2 urine samples within 2 weeks when not experiencing urinary symptoms. 

Objective 2: Participants in the metropolitan Washington DC area will be randomized into an intravesical Lactobacillus GG low dose or high dose group. Instillation will occur when experiencing urinary symptoms.  

Urine samples may be collected.

If you are interested or have questions, please contact;

Margot Giannetti
[email protected]
202-877-1071

 


Research Project 2

A Randomized Controlled Trial of Transcutaneous Tibial Nerve Stimulation (TTNS) for Neurogenic Lower Urinary Tract Dysfunction (NLUTD)

This study seeks to demonstrate that TTNS will improve NLUTD in SCI/D by intervening acutely, improving the QOL, by providing a feasible, non-pharmacologic and dignified intervention to be performed at home to reduce autonomic dysreflexia.

Participants must be:

  • Diagnosed with a Spinal Cord Injury or disease;
  • Level of injury T1-T9;
  • Aged 18-65;
  • Currently admitted to inpatient within 4 weeks of SCI/D at either MedStar National Rehabilitation Hospital (Washington DC), or TIRR Memorial Hermann (Houston, TX).

Participants will be in this study for 1 year and randomized into a low or high TTNS group.

If you are interested or have questions, please contact;

MedStar National Rehabilitation Hospital
Mandy Rounds, PhD     
[email protected]
202-877-1591                               

TIRR Memorial Hermann
Vanessa Bernal
[email protected]
713-797-7636


Research Project 3

A Mixed Methods Assessment of the Impact of the Connected CatheterTM on Quality of Life and Participation

Study Objective: The primary objective of this study is to evaluate if the burden of Neurogenic Lower Urinary Tract Dysfunction (NLUTD) on

  1. Health-related Quality of Life (QOL)
  2. Participation affected by type of bladder management
  3. Determine what constitutes a clinically meaningful difference in Neurogenic Lower Urinary Tract Dysfunction (NLUTD)-related QOL and participation and to identify NLUTD user-defined themes regarding bladder function and catheter-related barriers and the daily impacts on one’s life.

To be included in this study, participants must:

  • Have previous participation in a connected catheter study
  • Male
  • Be 18 years and older
  • Diagnosis of neurogenic lower urinary tract dysfunction

For interviews, caregivers of the above participants will be recruited.

If you are interested or have questions, please contact;

Mandy Rounds, PhD
[email protected]
202-877-1591