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Faculty Research

Mary Ann Dutton, PhDMary Ann Dutton PhD

Funding Source: National Institute of Health

Title: Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS)

Description: CTSA including Georgetown and Howard Universities, MedStar Health, DC VA Medical Center, and Oak Ridge National Laboratory.

Dr. Dutton is Co-Director of the Community Engagement and Research component, charged with supporting infrastructure for the successful implementation of community-based research, including aims to forge, expand, and sustain bi-directional partnerships with the public and community-based organizations in order to facilitate community participation in the development, conduct and dissemination of clinical and translational research (CTR}; to provide training and resources for investigators to enhance their community engagement and research skills, and to engage community-based practitioners in collaboratively conducting clinical and translational research; and to increase research subject participation by members of the diverse communities that make up the Washington, DC metropolitan area.

Role: Co-I, Co-Director, Community-Engagement Component

Funding Source: National Institutes of Health, Minority Health and Health Disparities

Title: Center of Excellence for Health Disparities in Our Nation’s Capital (CEHD)

Description: The aim of the new center is to eliminate or dramatically reduce health disparities in Washington, D.C., where chronic diseases disproportionately affect the largest minority group, African Americans. Dr. Dutton is a part of the CEHD’s Community Engagement Core, building and strengthening relationships between the scientific and lay communities to expedite evidence-based ways of impacting health disparities, focusing initially on stroke and breast cancer.

Role: Co-I

Funding Source: National Institute of Drug Abuse

Title: Diverting the Pathway to Substance Misuse by Improving Sleep

Description: The goal for this R34 proposal is to develop and test an intervention of which the primary target is disturbed sleep. The intervention will incorporate established sleep behavioral interventions, and include a novel component designed to address nocturnal vigilance, a prominent feature of post-deployment sleep interference. We will also assess overall alcohol and drug use in the target population, its relationship with sleep disturbance, include an educational/motivational module addressing substance use and sleep. We will assess the effect of participation on substance use and the degree to which the effect is accounted for by improvements in sleep.

Role: Co-I

Funding Source: Joyful Heart Foundation

Title: Holistic Healing Arts Retreat

Description: The purpose of the study is to evaluate the pre-, post- and long-term effects of a 5-day Holistic Healing Arts Retreat on perceived stress, secondary traumatic stress and quality of life among counselors and advocates working in one of three participating community clinics in or near Los Angeles, CA. This study is Part 1 of a two-part study, with Part 2 involving a similar retreat for adult female clients who have experienced some form of interpersonal violence (at least one of the following: childhood sexual abuse, domestic violence, sexual assault) of the same participating community clinics (separate IRB approval will be sought for Part 2). This study involves testing the effectiveness of a 5- day Holistic Healing Arts Retreat model for reducing stress and secondary traumatic stress and for improving the quality of life among female counselors and advocates who work with interpersonal violence victims.

Role: PI

Funding Source: VA Merit Grant

Title: Complementary and Alternative Medicine for Sleep, Health Functioning and Quality of Life for Veterans with Gulf War Illnesses

Description: Dr. Dutton is Professor of Psychiatry and has spent 31 years studying trauma exposure and its sequelae. She has completed both longitudinal risk factor studies and randomized clinical trials focused on PTSD. Dr. Dutton has designed and successfully implemented randomized clinical trials with very difficult to recruit and retain study populations, due both to their psychological condition, as well as to their socioeconomic status. Dr. Dutton is well aware of the challenges to recruitment and retention for clinical study populations and of the necessary measures to ensure participant safety and confidentiality. Dr. Dutton has received two federal grants addressing MBSR for PTSD. One of those, an NIMH-funded project, was a randomized clinical trial involving low-income, predominantly African American women exposed to chronic trauma, including interpersonal violence. The other, a DOD-funded project, focused on the development of an online mindfulness intervention for veterans with PTSD.

Role: Co-I

Funding Source: FY17 Toulmin Award, Georgetown University Medical Center

Title: Why Loneliness and Social Isolation Are So Deadly: Autophagy?

Description: According to a survey done in 2004, every fourth person in the US is lonely and lacks any confidants or social networks. Social isolation is especially common among elderly and individuals who have experienced physical violence or life-threatening trauma. Since social isolation is as equally powerful a predictor of early all-cause mortality than smoking, elevated blood pressure, high cholesterol or obesity, it is critical to identify and inhibit biological pathways mediating its adverse effects on health. We recently discovered in mice that social isolation induces autophagy, and autophagy is causally linked to increased breast cancer risk in isolated mice. Autophagy is a self-destructive process within our cells, called “self-eating”. It generates energy for cells and prevents them from being eliminated by “selfkilling” (apoptosis). Consequently, autophagy allows cancer cells to survive, even during cancer treatments. Autophagy also influences many other pathological processes that are induced by social isolation. In the study proposed here, we will investigate if social isolation in breast cancer patients induces autophagy in normal and malignant breast tissue and peripheral blood, compared with socially integrated individuals. The study will be done in breast cancer patients, as social isolation increases breast cancer mortality. If social isolation is found to induce autophagy in humans, we will next investigate whether reversing autophagy with FDA approved and well-tolerated drugs prevents adverse health effects in socially isolated individuals.

Role: PI


Dr. Alfiee M. Breland-NobleAlfiee M. Breland-Noble, PhD

Funding Source: PCORI (Eugene Washington Engagement Awards)

Title: Engaging Black Faith Communities to Address Mental Health Disparities via Curriculum Development

Description: The objectives of the proposed CBPR study are: 1) to investigate African American clergy and church leaders attitudes about depression and suicide in African Americans; 2) Determine the individual, interpersonal, environmental and contextual elements necessary to support Faith Based Health Promotion for child and family mental/behavioral health.

Role: PI

Funding Source: PCORI (Pipeline to Proposal Awards – Tier II)

Title: Building Capacity and Reducing Barriers to the Inclusion of Underserved Black Youth

Description: The objective of the proposed planning award is to fortify our current team of patients, caregivers, stakeholders, university researchers, providers and faith community leaders to develop a mental illness CER question.

Role: PI

Funding Source: GHUCCTS (Pilot Translational and Clinical Studies Program)

Title: Collaborating with African American/Black Faith Communities to Improve Engagement in Mental Health Comparative Effectiveness Research

Description: This proof of concept study is focused on quantifying and evaluating Faith Based Mental Health Promotion practices for engaging African Americans in mental health Comparative Effectiveness and Patient Centered Outcomes Research.

Role: PI

Funding Source: NIH/NIMH

Title: Center of Excellence for Health Disparities in our Nation’s Capital

Description: The focus of this Center of Excellence is to eliminate health disparities by transferring knowledge from research-to-practice-to-policy. Dr. Breland-Noble is a member of the Community Engagement Core providing expertise on rigorous mechanisms for engaging the local community in major projects of the center.

Role: Co-I

Funding Source: Georgetown University

Title: Georgetown Faculty Research Recognition Award

Description: Funding to support outstanding faculty contributions in the area of research.

Role: Award


Barbara Schwartz, Ph.D.Barbara Schwartz, Ph.D.

Funding Source: VA Capitol Network (VISN 5) Mental Illness Research, Education, Clinical Center (MIRECC)

Title: Exercise Encourages Recovery Trial (ExERT)

Description: Exercise induced Effects on Neurocognition in Schizophrenia (ended 2015)

Role: PI

Funding Source: Georgetown-Howard Universities Center for Clinical and Translational Science Pilot and Collaborative Studies Program

Title: Exercise in Schizophrenia: Impact on Cognition and Brain Plasticity (ended 2015)

Role: PI


Bruno J. Anthony, Ph.D.Bruno J. Anthony, Ph.D.

Funding Source: Substance Abuse and Mental Health Administration

Title: National Technical Assistance Center for Children’s Mental Health

Role: Director of Research and Evaluation

Funding Source: Administration on Developmental Disabilities (ADD)

Title: Georgetown University Center for Excellence in Developmental Disabilities, Education, Research and Service

Role: Director of Research

Funding Source: National Institute of Mental Health, NIH

Title: Developing Center for Improving Mental Health in Pediatric Primary Care

Role: Investigator, Director of Primary Research Core

Funding Source: NIH, National Institute on Minority Health and Health Disparities (NIMHD)

Title: Center of Excellence for Health Disparities in the Nation’s Capital

Role: Director, Research Training Core

Funding Source: Patient Centered Outcomes Research Institute (PCORI)

Title: A Community-Based Executive Function Intervention for Low-Income Children with ADHD and ASD

Role: PI

Funding Source: Substance Abuse and Mental Health Services Administration

Title: Substance Abuse and Mental Health Services Administration

Role: Faculty

Funding Source: Patient Centered Outcome Research Institute (PCORI)

Title: Improving Outcomes for Children with Mental Health Challenges and Their Families through Parent to Parent Peer Support (Tier I, Tier II)

Role: Research Advisor

Funding Source: Substance Abuse and Mental Health Services Administration

Title: Substance Abuse and Mental Health Services Administration

Role: Evaluator (American Institutes of Research, Prime)

Funding Source: Sesame Workshop

Title: See Amazing in All Children Evaluation

Role: PI


Dionne S. Coker-Appiah, PHD, MAED

Funding Source: Georgetown University Office of Global Engagement, International Collaborative Grant

Title: An International Collaboration to Prevent Gender-Based Violence in Ghana

Description: The purpose of this grant is to facilitate the process of engaging in focused and collaborative discussions and forward planning with community stakeholders interested in preventing Adolescent dating violence in Ghana. We recently traveled to Ghana and engaged in a three-phase Global Community-Engaged Research Planning Experience designed to gain a comprehensive and contextual understanding of GBV/ADV in Ghana. Phase I consisted of a two-day seminar that enabled GUMC faculty and community stakeholders to present ADV and other gender-based violence research, programs, and initiatives, and engage in relevant discussion regarding the collaborative development of future community-based GBV research projects. There are now several partners who have made a commitment to collaborate on a cultural adaptation grant proposal. Additional ideas regarding future research projects were generated during the seminar as well. Phase II consisted of a site visits to possible intervention implementation sites. Phase III consists of forward planning regarding the collaborative development of a grant proposal.

Role: PI

Funding Source: NIMHD Disparities Research and Education Advancing Mission (DREAM) Career Transition Award (K22)

Title: Project LOVE: Preventing Adolescent Dating Violence among Rural African Americans

Description: This project builds upon previous research by further developing a community-academic partnership that guides the design and evaluation of a dating violence prevention intervention for rural African American adolescents. The study aims are to: 1) further develop and evaluate the Project LOVE community-academic partnership and community advisory board (CAB); 2) design a culturally and geographically appropriate community-based ADV prevention intervention for rural African American adolescents aged 10-14; 3) assess the acceptability of the intervention through the use of focus group interviews; and 4) pilot test the intervention to evaluate the feasibility of intervention design.

Role: PI

Funding Source: Georgetown Office of the President, Reflective Engagement Grant

Title: Project Letting Our Voices Empower II: A coordinated community effort to explore and prevent dating violence among rural, African American adolescents

Description: The study aims are to: 1) expand and strengthen the existing Project LOVE community-academic partnership; and 2) use a CBPR approach and the SEM as a framework to guide a comprehensive assessment of ADV in Edgecombe and Nash Counties, from the perspective of both younger adolescents and community stakeholders; 2a) explore younger adolescents’ knowledge, perceptions/beliefs, and skills regarding ADV, as well as recommendations for intervention design using focus group interviews; 2b) explore community stakeholders knowledge, perceptions/beliefs and skills regarding ADV and identify community needs, assets, and resources that can be used to inform ADV prevention interventions, through the use of focus group interviews. Data from this project is being used to inform intervention development.

Role: PI

Funding Source: W.K. Kellogg Foundation

Title: Project LOVE I: Letting Our Voices Empower: Using CBPR to Explore Rural, African American Adolescents' Knowledge, Perceptions, and Beliefs about Dating Violence: Implications for Sexual and Mental Health

Description: This qualitative CBPR project explored (using semi-structured individual interviews) knowledge, perceptions, and beliefs about ADV among a sample of older adolescents (aged 18-21 years). The study aims are to: 1) explore rural African American adolescents’ knowledge, perceptions, and beliefs about dating violence and sexual health; 2) explore rural African American adolescents’ knowledge, perceptions, and beliefs about dating violence and mental health; and 3) explore rural African American adolescents’ perceptions about the impact of multilevel determinants on dating violence. Data from this project is being used to inform intervention development.

Role: PI


Elizabeth A. Hoge, M.D.

Funding Source: NIH/NHLBI

Title: Mindfulness-Based Stress Reduction for High Blood Pressure: A Two-Site RCT

Description: This project examines the effects of MBSR versus an attention control versus waitlist on blood pressure, in a population of unmedicated, pre-hypertensive adults.

Role: Co-Investigator

Funding Source: NIH/NCCIH

Title: 2/2 Yoga for Generalized Anxiety Disorder

Description: This study addresses an important public health issue by evaluating yoga as an intervention for generalized anxiety disorder, a common and disabling mental disorder. The study design will further provide valuable insight into the mechanisms of this intervention as compared to cognitive behavioral therapy. This proposal has direct treatment implications for practicing clinicians and might significantly reduce the personal suffering and the economic cost associated with a common anxiety disorder.

Role: Co-Investigator

Funding Source: NIH/NCCIH

Title: Mindfulness Influences on Self-Regulation: Mental and Physical Health Implications

Description: This project utilizes an interdisciplinary team of researchers from 4 universities (Harvard, Brown, UMass, Georgetown) to determine the most useful and precise measures of self-regulation, used in mindfulness research, that affect changes in health behaviors, and the most promising related modifications to Mindfulness-Based Intervention trials for managing chronic medical conditions.

Role: Investigator


Janice Krupnick, Ph.D.Janice Krupnick, PhD

Funding Source: VA

Title: Merit Award

Description: A four-year grant, testing interpersonal psychotherapy for PTSD versus exposure therapy in veterans. Treatments will be conducted at the Providence, RI and New Orleans VAs.

Role: Investigator


Karen E. Anderson, MDKaren E. Anderson, MD

Funding Source: National Institute of Neurological Disease and Stroke

Title: An Exploratory Phase II Study to Determine the Tolerability, Safety, and Activity of a Novel Vasopressin 1a Receptor Antagonist (SRX246) in Irritable Subjects with Huntington's Disease (HD)

Description: Dr. Anderson is a consultant on this study, and functions as the academic Co-PI for the entire study, which is being conducted at 23 NeuroNext Sites. This is a Phase II clinical trial of a vasopression angtagonist for treatment of irritability in Huntington’s Disease. Dr. Anderson’s role includes development of assessments for irritability, expertise on Huntington’s Disease in general, and expertise on clinical trial design and conduct in HD.

Role: Co-Investigator

Funding Source: Teva Pharmaceuticals

Title: OPEN PRIDE- Pridopidine Study in Huntington’s Disease

Description: Dr. Anderson is the site PI for this Open Label study of ACR-16 for Huntington’s Disease (HD). She is responsible for overseeing all study conduct involved in 3 to 6 month visits for the 7 subjects Georgetown rolled over from double blind to placebo controlled phase of the study. Pridopidine is a dopamine modulating drug that may increase cortical dopamine to help with attention and focus, which are impaired in HD. It may also decrease striatal dopamine, which would help to treat abnormal movements in HD.

Role: Site PI

Funding Source: Vaccinex Pharmaceuticals

Title: SIGNAL HD

Description: This is a North American Study of infusion treatment for slowing disease progression n Huntington’s Disease (HD). A monoclonal antibody is given once a month by intravenous infusion. Dr. Anderson is responsible for all study conduct for the 4 subjects Georgetown has enrolled in this study. Subjects are seen on a monthly basis for infusion treatments over a 12 month period.

Role: Investigator

Funding Source: Teva/Auspex Pharmaceuticals

Title: ARM TD

Description: This is a titration study of SD-809, a dopamine depleting VMAT2 inhibitor, for treatment of tardive dyskinesia (TD). TD is an abnormal involuntary movement disorder associated with use of neuroleptics and other dopamine blocking agents. In this study, dose of SD-809 is titrated to individual subject needs/preferences. Dr. Anderson is the global Co-PI for the study. In this role, she provides oversight of the 60+ sites in North America and Europe conducting this study. She is involved in study design and conduct, data interpretation, and manuscript writing.

Role: Co-Investigator

Funding Source: Teva/Auspex Pharmaceuticals

Title: AIM TD

Description: This is a fixed dose study of SD-809, a dopamine depleting VMAT2 inhibitor, for treatment of tardive dyskinesia (TD). TD is an abnormal involuntary movement disorder associated with use of neuroleptics and other dopamine blocking agents. In this study, dose of SD-809 is escalated on a fixed schedule, in contrast to the individual titration in the ARM study. Dr. Anderson is the global Co-PI for the study. In this role, she provides oversight of the over 60 sites in North America and Europe conducting this study. She is involved in study design and conduct, data interpretation, and manuscript writing.

Role: PI

Funding Source: Teva Pharmaceuticals

Title: LEGATO HD study

Description: This is a global study of 400 HD patients treated with laquinimod versus placebo over a one year period. Laquinimod, which was developed for multiple sclerosis, may help to modulate dysfunctional immune response in Huntington’s Disease. Dr. Anderson is the North American Co-PI for the study. In this role, she provides oversight to 13 study sites. She is also involved in study design and interpretation of data, and manuscript production.

Role: Co-PI

Funding Source: CHDI Foundation

Title: ENROLL HD Observational Study

Description: This is a global, 10 year observational study of over 10,000 people from Huntington’s Disease (HD) families. As the site PI for Enroll at Georgetown, Dr. Anderson is responsible for study conduct during yearly visits for the 130 subjects enrolled at this site.

Role: Investigator


Kimberly Davis, Ph.DKimberly Davis, PhD

Funding Source: NIH/NCI

Title: Treatment Decisions and Patient Reported Outcomes in Low Risk Prostate Cancer (now in a no-cost extension)

Role: Co-Investigator

 


Matthew Biel, M.D., M.Sc.Matthew Biel, MD

Funding Source: J. Willard and Alice S. Marriott Foundation

Title: Early Childhood Innovation Network

Description: The Early Childhood Innovation Network is a community-based project designed to identify and implement promising interventions to build resilience among families facing adversity in Washington, D.C. ECIN projects are designed to enable families and those who support them, such as pediatricians, child care providers, and social service agencies, to intervene early and prevent or decrease the influences of toxic stress.

Role: Co-PI


Matthew J. Reinhard, Ph.D.Matthew J. Reinhard, Ph.D.

No current research support with Georgetown University.

 

 

 


Mihriye Mete, Ph.D.Mihriye Mete, Ph.D.

Funding Source: National Institute of Health

Title: Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS)

Description: CTSA including Georgetown and Howard Universities, MedStar Health, DC VA Medical Center, and Oak Ridge National Laboratory.

Role: Dr. Mete is a member of the BERD team. She conducts data analyses, provides consulting for research design, she reviews IRB protocols, grant applications and manuscripts to support GHUCCTS investigators.

Funding Source: Joyful Heart Foundation

Title: Holistic Healing Arts Retreat

Description: The purpose of the study is to evaluate the pre-, post- and long-term effects of a 5-day Holistic Healing Arts Retreat on perceived stress, secondary traumatic stress and quality of life among counselors and advocates working in one of three participating community clinics in or near Los Angeles, CA. This study is Part 1 of a two-part study, with Part 2 involving a similar retreat for adult female clients who have experienced some form of interpersonal violence (at least one of the following: childhood sexual abuse, domestic violence, sexual assault) of the same participating community clinics (separate IRB approval will be sought for Part 2). This study involves testing the effectiveness of a 5- day Holistic Healing Arts Retreat model for reducing stress and secondary traumatic stress and for improving the quality of life among female counselors and advocates who work with interpersonal violence victims. The primary outcomes are

Role: Statistician.

Funding Source: VA Merit Grant

Title: Complementary and Alternative Medicine for Sleep, Health Functioning and Quality of Life for Veterans with Gulf War Illnesses

Role: Statistician.

Funding Source: VA Merit Grant

Title: Interpersonal Therapy for Veterans with PTSD

Role: Statistician.

Funding Source: National Institute of Health

Title: R34: Diabetes To Go-Inpatient

Role: Statistician.

Funding Source: Diabetes Pathway

Title: Medstar Health sponsored Implementation Study

Role: Dr. Mete is the statistician for this study and also supervises Return on Investment analyses Medstar-wise.

Funding Source: Early Childhood Innovation Network

Role: Dr. Mete’s role in this study is to provide expertise on evaluation and also to supervise database creation and management at MHRI.


Pamela A. Saunders, Ph.D.Pamela A. Saunders, Ph.D.

No current research support.

 

 

 


Priscilla Dass-Brailsford, Ph.D.Priscilla Dass-Brailsford, EdD

Title: The Role of Traditional Healers in Treating Mental Health Issues in South Africa

Description: Given the widespread use of traditional medicine, especially among poorer population groups, it is important to explore the training, expertise, and skills of traditional healers and why this health-care system is viewed positively and more beneficial compared to mainstream mental health care. The goal of this study is to conduct a qualitative research on the traditional healing practices in South Africa.

Role: PI

Title: An exploration of traumatic effects of political violence among the Kakchiqueles living in Sololá, Guatemala

Description: This exploratory study was conducted among the Kakchiqueles, a Mayan population that has experienced political torture; witnessed the destruction of their homes and neighborhood; experienced the massacre of entire communities and war-related upheaval. The purpose of this study was to look at the effects of these traumatic experiences on this population and compare their reactions to DSMV criteria.

Role: PI


Richard L. Amdur, Ph.D.Richard L. Amdur, Ph.D.

 

 

 

 


Stacey Kaltman, Ph.D.Stacey Kaltman, PhD

Funding Source: MedStar Diabetes Fund

Title: Shaping the Future of Diabetes Care: Feasibility of virtually integrated boot camp co-management of diabetes and mental health

Description: The goal of this pilot study is to assess the feasibility of integrating a focused “survival skills” behavioral intervention for patients identified as having mild-moderate depression and/or anxiety into an established, evidence-based, MedStar Diabetes Pathway 12 week “Boot Camp” program for adult patients with uncontrolled Type 2 diabetes. Twenty patients will be recruited and consented to participate from two large primary care practices on the MedStar Washington Hospital Center campus. Much of the intervention will be delivered using telehealth “virtual visits” (via phone/text/email/skype-equivalent) after two face-to-face meetings with the team, thus overcoming barriers to accessing care. We will also determine the preliminary efficacy of the diabetes and mental health co-management intervention by assessing the correlation of A1C reduction with improvement in depression and anxiety scores.

Role: PI


Celene E. Domitrovich, Ph.D.Celene E. Domitrovich, Ph.D.

Funding Source: Marriott Foundation

Title: Early Childhood Innovation Network

Description: Dr. Domitrovich is the Research Director for the Early Childhood Innovation Network, a collaborative effort between Georgetown University Department of Psychiatry and Children’s National Health System. The mission of ECIN is to ensure that all children in Washington, DC are able to thrive and reach their fullest potential by taking a science-based and cross-sector approach to strengthening families and the systems which support them and decreasing the impact of trauma and toxic stress on the children of our community. The four core strategies of education, action, research, and advocacy will anchor the ECIN’s efforts across the city.

Role: Research Director

Funding Source: Department of Education, Investing in Innovation Fund

Title: Enhancing Outcomes of an Evidence-Based Social-Emotional Program with a School Support Model

Description: Non-cognitive skills promote engagement in learning, relationships with teachers and peers, and long-term academic success. Nurturing these skills in students is a pathway to higher academic achievement, especially for low performing schools. Evidence-based social-emotional learning (SEL) programs such as PATHS® promote these skills in students but are often implemented poorly and without planning or integration with other school activities. The CASEL SchoolKit is a school-wide support intervention that includes multiple strategies to build capacity and support for SEL programs such as PATHS® and to integrate and coordinate them into all aspects of the school’s functioning.

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